Figure 3
From: In vitro mutation artifacts after formalin fixation and error prone translesion synthesis during PCR
Mutation spectra. Differed between fresh (five mutations) and fixed (76 mutations) DNA, with marked increases in transition mutations, and additions or deletions at short repeat sequence. Mutations in the fixed DNA specimens appear randomly distributed. Graphed are mutation locations for the 380 base pair sequenced region within the 420 base pair PCR product (APC bases 4063 to 4442, GenBank Accession NM_000038.2).