Table 1 PI3K expression patterns in normal human tissues.
Human Tissues | n | Histological Structure | p85 | PI3K-C2α | PI3K-C2β | Figure |
|---|---|---|---|---|---|---|
Digestive system | ||||||
Stomach | 3 | Peptic (chief) cells | +++ | ++ | ++ | 2A |
Parietal (oxyntic) cells | - | - | - | |||
Gastric mucous cells | - | - | - | |||
Small intestine | 7 | Enterocytes | +++ | ++ | + | 2B |
Paneth cells | ++ | - | - | |||
Goblet cells | - | - | - | |||
Colon | 10 | Colonocytes | ++ | ++ | ++ | 2C |
Goblet cells | - | - | - | |||
Features common to all GIT | Mononuclear cells | +++ | ++ | +++ | 2D | |
Muscular layers | - | ++ | - | |||
Ganglion cells | +++ | - | +++ | 2E | ||
Non-myelinated nerves | - | - | ++ | 2E | ||
Neuroendocrine cells | - | - | - | |||
Respiratory system | ||||||
Lung | 5 | Pneumocytes (Types I and II) | - | - | - | |
Alveolar Macrophages | ++ | ++ | ++ | 2F | ||
Bronchi | Bronchial Epithelium | + | + | + | ||
Bronchial glands | - | - | - | |||
Cartilage | - | - | - | |||
Bronchial smooth muscle | - | ++ | - | |||
Skin and Integument | 5 | Stratified squamous epithelium | - | - | - | 2G |
Melanocytes | - | - | - | |||
Sebaceous glands | + | - | - | 2G | ||
Hair follicle | + | - | - | 2H | ||
Sweat Glands | + | + | - | 2H | ||
Langerhans cells | ++ | - | - | 2I | ||
Dermal macrophages | ++ | ++ | ++ | 2I | ||
Female reproductive system | ||||||
Uterus | 3 | Proliferative Endometrium | ++ | - | - | 2J |
3 | Secretory Endometrium | + | - | - | 2K | |
Endometrial Stroma | - | - | - | |||
Myometrium | - | ++ | - | |||
Cervix | 3 | Ectocervical squamous epithelium | - | - | - | |
Endocervical glands | - | - | - | 2L | ||
Cervical smooth muscle | - | ++ | - | |||
Ovary | 3 | Follicular cells | ++ | + | + | 2M |
Germinal cells | - | - | - | |||
Stromal cells | - | - | - | |||
Corpus luteum | ND | ND | ND | |||
Fallopian tube | 2 | Columnar ciliated epithelium | +++ | ++ | + | 2N |
Mammary gland (breast) | 3 | Luminal acinar epithelium | - | - | - | 2O |
Myoepithelial cells | - | + | - | |||
Lactiferous ducts | - | + | - | |||
Male reproductive system | ||||||
Testis | 3 | Spermatogenic cells | +++ | - | +++ * | 2P, 2Q * |
Sertoli cells | - | - | - | |||
Leydig cells | ++ | +++ | ++ | |||
Prostate gland | 10 | Basal Epithelium | - | + | - | |
Luminal epithelium | - | - | - | |||
Fibromuscular stroma | - | ++ | - | |||
Urinary system | ||||||
Urinary bladder | 5 | Transitional epithelium | ++ | ++ | ++ | 2R |
Muscularis | - | ++ | - | |||
Kidney | 10 | Glomerular macrophages | ++ | - | ++ | 3A |
Glomerular tuft | - | +++ | - | 3B | ||
Proximal Tubules | - | + | + | |||
Macula Densa | ++ | - | - | 3A | ||
Distal tubules | - | + | + | |||
Collecting tubules | +++ | + | + | |||
Pancreas | 5 | Acini | +++ | ++ | - | 3C, 3D |
Ducts | - | ++ | - | 3D | ||
Islets of Langerhans | - | - | - | 3C | ||
Hepatobiliary system | ||||||
Liver | 4 | Hepatocytes | - | - | - | |
Bile ducts | - | ++ | - | |||
Kupffer cells | - | - | - | |||
Gall bladder | 4 | Lining epithelium | + | + | + | |
Smooth muscle layer | - | ++ | - | |||
Mononuclear cells | ++ | ++ | ++ | |||
Endocrine System | ||||||
Thyroid | 3 | Follicular/Parafollicular | - | - | - | |
Parathyroid | 3 | Oxyphil/Chief | - | - | - | |
Endocrine Pancreas | Islets of Langerhans | - | - | - | ||
Lymphoid tissue & Immune cells | ||||||
Spleen | 5 | White pulp | - | - | - | |
Red pulp (mononuclear cells) | ++ | + | ++ | 3E | ||
Red pulp (splenic sinusoids) | - | +++ | - | 3F | ||
Lymph nodes | 5 | Lymphoid follicles | - | - | - | |
Germinal centre mononuclear cells | ++ | + | + | |||
Medulla (mononuclear cells) | ++ | + | ++ | |||
Tissue macrophages | +++ | ++ | ++ | 3G | ||
Polymorphnuclear leucocytes | + | +++ | - | 3H | ||