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Figure 3 | BMC Clinical Pathology

Figure 3

From: Topographical expression of class IA and class II phosphoinositide 3-kinase enzymes in normal human tissues is consistent with a role in differentiation

Figure 3

Contrasting expression of p85 (left panels) and PI3K-C2α (right panels) in the kidney (A, B), pancreas (C, D), spleen (E, F) and immune cells (G, H). In the kidney, p85 was expressed in glomerular macrophages (see inset) and in the macula densa (MD) (A) while PI3K-C2α labelled the glomerular tuft (B). Closer examination of the marked area (inset), expression is observed to be epithelial (P) rather than endothelial (C) or mesangial (M). Pancreatic acinar cells expressed p85 in a cytoplasmic subnuclear position(C) while PI3K-C2α highlighted intercalated ducts (D). Mononuclear cells (macrophages) in the splenic red pulp were reactive for p85 (E). PI3K-C2α was observed in macrophages and in splenic sinusoids, in an interrupted bead-like manner (F). Acute inflammatory cells (arrow head) adhering to the wall of a dilated capillary (C) are not reactive for p85 (G) but express PI3K-C2α (H). Tissue macrophages expressed p85 (membranous expression is marked by arrows) and cytoplasmic PI3K-C2α. (Original magnification A, C, D and E × 400), (B × 200), (F-H × 1000)

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BMC Clinical Pathology

ISSN: 1472-6890

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