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Table 3 miR-21 in tumor cells and stroma as predictors for disease-specific survival in NSCLC patients (univariate analysis; log-rank test) and results of Cox regression analysis summarizing significant independent prognostic factors

From: High tumor cell expression of microRNA-21 in node positive non-small cell lung cancer predicts a favorable clinical outcome

Characteristics Pts (n) Pts (%) Median survival (months) 5-Year survival (%) Univariate (P) Multi-variate (P) HR 95% CI
Total (n = 335)      0.45 0.71 1.08
 Low 220 66 190 61    0.73-1.60
 High 98 29 98 55    
 Missing 17 5      
Tumor 1 (n = 335)      0.65 0.40 1.20
 Low 60 18 NR 59    0.74-1.95
 High 258 77 127 59    
 Missing 17 5      
  N0 (n = 223)      0.091 0.33 0.69
   Low 43 19 NR 75    0.33-1.45
   High 180 81 190 66    
  N+ (n = 95)      0.024 0.027 2.03
   Low 17 18 17 18    1.09-3.78
   High 78 82 37 42  
Stroma 2 (n = 335)      0.022 0.12 0.45
 Low 21 6 189 89    0.16-1.24
 High 301 90 127 57    
 Missing 13 4      
  N0 (n = 225)      0.044 0.061 0.32
   Low 16 7 190 93    0.08-1.38
   High 209 93 NR 66    
  N+ (n = 97)      0.44 0.45 0.58
   Low 5 5 71 75    0.14-2.37
   High 92 95 27 36    
  1. NR = not reached.
  2. 1Tumor cells.
  3. 2Cells of the peritumoral connective tissue (fibroblasts, mesenchymal cells, immune cells, endothelial cells, pericytes and extracellular matrix.
  4. Statistically significant results in bold font.