Table 3 Association of clinicopathological parameters and EphA1, A4, A5 and A7 expression with patients’ survival: Univariate analysis
Clinicopathological variables | Overall patients’ survival | |
|---|---|---|
HR (95% CI) | p-value | |
Age (≤64.47 ± 9.18 / > 64.47 ± 9.18 yrs) | 1.148 (0.743-1.773) | 0.535 |
Gender (Male/Female) | 0.823 (0.472-1.437) | 0.494 |
Histopathological type (Adenocarcinoma/Squamous) | 1.776 (1.127-2.800) | 0.013 |
Histopathological grade (I + II/III) | 1.492 (0.944-2.360) | 0.087 |
Smoking status (Yes/No) | 1.331 (0.680-2.608) | 0.404 |
Alcohol consumption (Yes/No) | 0.942 (0.608-1.461) | 0.791 |
Performance status (0–1/2) | 2.178 (1.142-4.155) | 0.018 |
Inflammation (Yes/No) | 1.354 (0.791-2.317) | 0.269 |
Lymphovascular invasion (Yes/No) | 0.666 (0.414-1.071) | 0.094 |
Necrosis (Yes/No) | 0.742 (0.477-1.155) | 0.186 |
Fibrosis (Yes/No) | 0.637 (0.364-1.115) | 0.114 |
Tumor size (T1/T2-4) | 2.037 (1.121-3.700) | 0.020 |
Lymph node metastases (N0-1/N2-3) | 2.323 (1.597-3.380) | <0.001 |
Distant metastases (M0/M1) | 4.971 (2.057-12.014) | <0.001 |
Histopathological stage (I + II/III + IV) | 2.493 (1.576-3.945) | <0.001 |
EphA1 expression (Negative/Weak vs Moderate/Strong) | 0.798 (0.448-1.423) | 0.444 |
EphA4 expression (Negative/Weak vs Moderate/Strong) | 0.556 (0.334-0.928) | 0.025 |
EphA5 expression (Negative/Weak vs Moderate/Strong) | 0.542 (0.345-0.853) | 0.012 |
EphA7 expression (Negative/Weak vs Moderate/Strong) | 0.574 (0.365-0.901) | 0.016 |