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Table 4 Multivariate analyses of clinopathological variables and angiogenic markers as prognostic values for disease-specific survival, metastasis and local recurrence in patients with resected soft-tissue sarcomas of the trunk or extremities (cox proportional hazards test)

From: The VEGF- and PDGF-family of angiogenic markers have prognostic impact in soft tissue sarcomas arising in the extremities and trunk

 

Disase-specific survival

 

Metastasis-free survival

 

Recurrence-free survival

 

Variable

HR

95% CI

P

HR

95% CI

P

HR

95% CI

P

Extremity & trunk

Malignancy grade

         

1

1.000

 

<0.001*

      

2

4.066

1.389-11.901

0.010

      

3

6.025

2.058-17.634

0.001

      

Vascular invasion

         

Absent

1.000

  

1.000

  

1.000

  

Present

2.141

1.188-3.859

0.011

5.284

2.418-11.544

<0.001

2.135

1.019-4.475

0.045

Resection margins

         

Wide

1.000

     

1.000

  

Non-wide

1.818

1.032-3.203

0.039

   

2.687

1.289-5.602

0.008

PDGF-B

         

Low

      

1.000

  

High

      

2.099

0.937-4.706

0.072

PDGF-D

         

Low

1.000

     

1.000

  

High

1.863

1.057-3.283

0.031

   

1.844

0.931-3.653

0.079

VEGF-A

         

Low

      

1.000

  

High

      

2.095

1.028-4.271

0.042

VEGFR-1

         

Low

   

1.000

     

High

   

2.106

1.038-4.272

0.039

   

Visceral & retroperitoneal

Gender

         

Male

   

1.000

     

Female

   

4.612

1.089-19.536

0.038

   

Malignancy grade

         

1

1.000

 

0.003*

   

1.000

 

0.061

2

4.812

1.823-12.705

0.002

   

2.069

0.630-6.794

0.231

3

5.646

1.790-17.804

0.003

   

5.665

1.330-24.123

0.019

Resection margins

         

Wide

1.000

     

1.000

  

Non-wide

2.712

1.222-6.018

0.014

   

11.996

3.128-46.005

<0.001

PDGF-C

         

Low

      

1.000

  

High

      

0.413

0.157-1.089

0.074

FGFR-1

         

Low

1.000

        

High

0.243

0.095-0.618

0.003

      
  1. Abbreviations: HR Hazard ratio, CI Confidence interval, VEGF Vascular endothelial growth factor, VEGFR Vascular endothelial growth factor receptor, PDGFR Platelet-derived growth factor receptor, FGFR Fibroblast growth factor receptor, *overall significance as prognostic factor.