BMC Clinical Pathology

Table 2 Angiogenic markers as predictors for disease-specific survival, metastasis and local recurrence in patients with resected soft-tissue sarcomas of the extremities or trunk (univariate analyses, log rank test, n = 115)

From: The VEGF- and PDGF-family of angiogenic markers have prognostic impact in soft tissue sarcomas arising in the extremities and trunk

		Disase-specific survival		Metastasis-free survival		Recurrence-free survival
Marker expression	Patients (n)	5-Year survival (%)	P	5-Year survival (%)	P	5-Year survival (%)	P
PDGF-A
Low	54	60	0.035	74	0.007	79	0.012
High	58	52		51		55
Missing	3
PDGF-B
Low	44	68	0.006	78	0.003	82	0.015
High	68	48		52		56
Missing	3
PDGF-C
Low	31	71	0.032	68	0.214	68	0.564
High	80	50		61		65
Missing	4
PDGF-D
Low	73	67	0.003	70	0.051	77	0.002
High	40	34		49		42
Missing	2
PDGFR-α
Low	69	67	0.002	74	0.002	77	0.011
High	43	38		42		45
Missing	3
PDGFR-β
Low	85	64	0.029	72	0.002	69	0.825
High	24	32		35		58
Missing	6
VEGF-A
Low	60	65	0.001	75	0.001	77	0.002
High	51	43		48		51
Missing	4
VEGF-C
Low	69	55	0.476	68	0.083	68	0.232
High	38	60		56		63
Missing	8
VEGF-D
Low	84	57	0.131	67	0.081	70	0.177
High	29	50		51		55
Missing	2
VEGFR-1
Low	67	63	0.002	77	<0.001	72	0.036
High	44	46		43		58
Missing	4
VEGFR-2
Low	78	58	0.332	67	0.189	71	0.240
High	28	52		53		57
Missing	9
VEGFR-3
Low	75	60	0.053	70	0.008	70	0.159
High	34	45		46		57
Missing	6
FGF2
Low	75	61	0.033	66	0.214	70	0.648
High	35	49		56		67
Missing	6
FGFR-1
Low	83	58	0.460	64	0.411	66	0.768
High	26	47		55		71
Missing	6

Abbreviations: PDGF Platelet-derived growth factor, PDGFR Platelet-derived growth factor receptor, VEGF Vascular endothelial growth factor, VEGFR Vascular endothelial growth factor receptor, FGF Fibroblast growth factor, FGFR Fibroblast growth factor receptor.

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ISSN: 1472-6890

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