Relationship between adiponectin and markers of insulin resistance | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Univariable | Multivariable | |||||||||||
Adjusted for BMI | Adjusted for duration of therapy | Adjusted for BMI and duration of therapy | ||||||||||
b | 95% CI | p-value | b | 95% CI | p-value | b | 95% CI | p-value | b | 95% CI | p-value | |
Total Adiponectin | ||||||||||||
Waist | -0.27 | (-0.3895,-0.1420) | 0.0001** | -0.28 | (-0.5153,-0.0517) | 0.019* | -0.29 | (-0.4582,-0.1161) | 0.002* | -0.35 | (-0.6479,-0.0492) | 0.028* |
Fasted Insulin | -0.28 | (-0.4683,-0.0906) | 0.005* | -0.21 | (-0.3945,-0.0164) | 0.037* | -0.28 | (-0.5408,-0.0266) | 0.036* | -0.24 | (-0.4935,0.0099) | 0.067 |
HOMA-IR | -1.11 | (-1.8677,-0.3428) | 0.006* | -0.81 | (-1.5741,-0.0551) | 0.040* | -1.21 | (-2.3196,-0.1036) | 0.038* | -1.07 | (-2.1435,0.0051) | 0.058 |
QUICKI | 14.20 | (1.2607,27.1444) | 0.035* | 8.24 | (-4.8207,21.3036) | 0.221 | 15.25 | (-0.2780,30.7806) | 0.061 | 11.29 | (-4.4271,26.9992) | 0.167 |
HMW Adiponectin | ||||||||||||
Waist | -0.17 | (-0.2484,-0.0923) | 0.0001** | -0.19 | (-0.3350,-0.0429) | 0.014* | -0.16 | (-0.2637,-0.0627) | 0.003* | -0.19 | (-0.3674,-0.0109) | 0.044* |
Fasted Insulin | -0.17 | (-0.2941,-0.0547) | 0.006* | -0.13 | (-0.2475,-0.0078) | 0.041* | -0.17 | (-0.3204,-0.0169) | 0.035* | -0.14 | (-0.2918,0.0048) | 0.065 |
HOMA-IR | -0.69 | (-1.1753,-0.2091) | 0.007* | -0.51 | (-0.9903,-0.0273) | 0.042* | -0.72 | (-1.3745,-0.0666) | 0.037* | -0.64 | (-1.2681,-0.0022) | 0.056 |
QUICKI | 9.38 | (1.2388,17.5231) | 0.027* | 5.67 | (-2.5563,13.9009) | 0.182 | 9.97 | (0.9112,19.0352) | 0.037* | 7.66 | (-1.5098,16.8289) | 0.110 |
HMW: TA | ||||||||||||
Waist | -0.007 | (-0.0102,-0.0042) | 0.000** | -0.011 | (-0.0165,-0.0054) | 0.0003** | -0.16 | (-0.2637,-0.0627) | 0.003* | -0.007 | (-0.0130,-0.0016) | 0.016* |
Fasted Insulin | -0.008 | (-0.0123,-0.0030) | 0.002* | -0.006 | (-0.0109,-0.0014) | 0.013* | -0.007 | (-0.0119,-0.0025) | 0.005* | -0.006 | (-0.0111,-0.0018) | 0.009* |
HOMA-IR | -0.03 | (-0.0497,-0.0123) | 0.002* | -0.03 | (-0.0442,-0.0063) | 0.011* | -0.03 | (-0.0509,-0.0103) | 0.005* | -0.03 | (-0.0479,-0.0084) | 0.008* |
QUICKI | 0.42 | (0.1036,0.7331) | 0.011* | 0.30 | (-0.0230,0.6253) | 0.073 | 0.44 | (0.1586,0.7148) | 0.004* | 0.38 | (0.0911,0.6598) | 0.014* |