Figure 1

Histopathologic images from Dual-Modular Neck group. A) Periprosthetic neosynovium with polypoid hypertrophy (whole mount). B) Neo-synovial membrane with lining layer composed of macrophages, marked stromal sclerosis, and perivascular lymphocytic infiltrate (x100). C) Perivascular lymphocytic infiltrate associated with particle-laden macrophages (x400). D) Papillary synovium with marked perivascular lymphocytic infiltrate (x40) associated to giant cells containing corrosion products (inset x400). E) Late stage of adverse reaction with thick layer of necrosis/infarction and deep seated inflammatory infiltrate (whole mount). F) Band-like inflammatory infiltrate composed of macrophages, lymphocytes, plasma cells, and eosinophils (x400). G) Granulomatous pattern composed of small granulomas with multi-nucleated giant cells and lymphocytic cuffing (x100). H) Bone marrow involvement with area of necrosis (black arrow) and mixed macrophagic and lymphocytic infiltrate with resorptive osteoclastic activity (x100).