Table 1 Comparison of clinicopathological variables between 80 OSCC patients with and without TLSs using Pearson’s Chi-square test
TLS-negative | TLS-positive | P-value | |
|---|---|---|---|
(N = 63) (no. (%)) | (N = 17) (no. (%)) | ||
Gender | |||
Male | 35 (55.6) | 11 (64.7) | 0.498 |
Female | 28 (44.4) | 6 (35.3) | |
Age at diagnosis, years | |||
Mean | 63.19 | 63.71 | 0.178 |
0-59 | 23 (36.5) | 6 (35.3) | 0.926 |
≥ 60 | 40 (63.5) | 11 (64.7) | |
Smoking history | |||
Never smoker | 14 (22.2) | 4 (23.5) | |
Former smoker | 10 (15.9) | 1 (5.9) | 0.722 |
Current smoker | 34 (54.0) | 11 (64.7) | |
Unknown | 5 (7.9) | 1 (5.9) | |
Alcohol consumption | |||
Never | 12 (19.0) | 1 (5.9) | |
≤ 1 times weekly | 24 (38.1) | 6 (35.3) | 0.114 |
> 1 times weekly or daily | 17 (27.0) | 3 (17.6) | |
Unknown | 10 (15.9) | 7 (41.2) | |
Tumour site | |||
Mobile tongue | 29 (46.0) | 9 (52.9) | |
Floor of mouth | 17 (27.0) | 5 (29.4) | |
Soft palate | 1 (1.6) | 0 (0.0) | 0.956 |
Buccal mucosa | 7 (11.1) | 1 (5.9) | |
Alveolar ridge | 8 (12.7) | 2 (11.8) | |
Unknown | 1 (1.6) | 0 (0.0) | |
Tumour differentiation | |||
Well | 20 (31.7) | 10 (58.8) | |
Moderate | 39 (61.9) | 5 (29.4) | 0.058 |
Poor | 4 (6.3) | 2 (11.8) | |
T stage | |||
T1 | 23 (36.5) | 6 (35.3) | |
T2 | 18 (28.6) | 9 (52.9) | 0.187 |
T3, T4 | 21 (33.3) | 2 (11.8) | |
Unknown | 1 (1.6) | 0 (0.0) | |
N stage | |||
N0 | 41 (65.1) | 13 (76.5) | |
0.670 | |||
N+ | 17 (27.0) | 3 (17.6) | |
Unknown | 5 (7.9) | 1 (5.9) | |
M stage | |||
M0 | 57 (90.5) | 17 (100.0) | |
M+ | 1 (1.6) | 0 (0.0) | 0.417 |
Unknown | 5 (7.9) | 0 (0.0) | |
Treatment | |||
Surgery local +/− neck resection | 7 (11.1) | 2(11.8) | |
Surgery and radiotherapy | 41 (65.1) | 12 (70.6) | |
Radiotherapy +/− chemotherapy | 8 (12.7) | 3 (17.6) | 0.700 |
None or palliative | 5 (7.9) | 0 (0.0) | |
Unknown | 2 (3.2) | 0 (0.0) | |
HPV/p16 | |||
Negative | 52 (82.5) | 16 (94.1) | |
Positive | 5 (7.9) | 1 (5.9) | 0.386 |
Unknown | 6 (9.5) | 0 (0.0) |