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Figure 2 | BMC Clinical Pathology

Figure 2

From: Characterisation and prognostic value of tertiary lymphoid structures in oral squamous cell carcinoma

Figure 2

Tertiary lymphoid structures in oral squamous cell carcinoma. The pictures show representative immunohistochemical stainings on consecutive sections of the same oral squamous cell carcinoma (OSCC) tissue sample for detection of classical tertiary lymphoid structures (TLSs). A section that presents clusters of CD20+ B-cells (A) typically shows organized accumulations of follicular dendritic cells (FDCs) in a consecutive section stained for CD21 (B). T-cell areas within and around the B-cell follicle are found by staining another consecutive section for CD3 (C). High-endothelial venules (HEVs) adjacent to the B-cell follicle are detected when staining a consecutive section for PNAd, as shown in (D). CD20+, CD21+ and CD3+ cells as well as PNAd + vessels are stained brown, and cell nuclei are stained blue by hematoxylin. Germinal centres are labelled “GC” and stroma surrounding the TLS is labelled “S” in the micrographs. Scale bars indicate 40 μm.

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