Expression of KOC, S100P, mesothelin and MUC1 in pancreatico-biliary adenocarcinomas: development and utility of a potential diagnostic immunohistochemistry panel

Table 2 Summary statistics of KOC, S100P, mesothelin and MUC1 expression on a per core basis comparing pancreatico-biliary adenocarcinomas with normal tissue

Biomarkers		Pancreaticobiliary adenocarcinoma	Normal tissue	P value
KOC
Positivity*	Mean	74%	0.4%	<0.0001
Positivity*	Median	100%	0%
Histoscore	Mean	150	0.5	<0.0001
Histoscore	Median	180	0
S100P
Positivity	Mean	75%	0.3%	<0.0001
Positivity	Median	100%	0%
Histoscore	Mean	165	0.3	<0.0001
	Median	180	0
Mesothelin
Positivity	Mean	73%	4%	<0.0001
Positivity	Median	90%	0%
Histoscore	Mean	115	4	<0.0001
Histoscore	Median	110	0
MUC1
Positivity	Mean	75%	18%	<0.0001
	Median	90%	10%
Histoscore	Mean	193	48	<0.0001
	Median	200	30

Note: *Positivity (percentage of positive cells with any staining intensity in tumour and normal tissue); P value (shows the statistical significance of the difference in expression of a biomarker in tumour vs. normal tissue); Positivity range (0–100), Histoscore range (0–300).

ISSN: 1472-6890