* Combined Summary ROC curves for 10 % (A) and 20% (B) cut-offs if only one biomarker was required to be positive in a panel. Four panels of biomarkers were compared. Panel 1 - KOC, S100P, Mesothelin and MUC1; Panel 2 - KOC, S100P, Mesothelin; Panel 3 - KOC, S100P; Panel 4 - KOC, Mesothelin. *Summary ROC curves plot sensitivity against specificity and draw a summary line depicting combined sensitivity and specificity of a panel. Combined Summary ROC curves compare different panels to show the most “accurate” panel. The summary line at the top left corner shows the biomarker which is most accurate compared to others lying lower and further to the right. This enables the most accurate panel to be identified.