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Table 3 Estradiol immunoassay cross-reactivity

From: Cross-reactivity of steroid hormone immunoassays: clinical significance and two-dimensional molecular similarity prediction

Compound

Plasma/serum concentrations

Cross-reactivity in Roche assay

Likelihood of clinically significant cross-reactivity

Estradiol (endogenous compound)

• 0.01 – 0.04 ng/mL (males) [37]

100%

High (assay target)

• 0.013 – 0.50 ng/mL (premenopausal females) [37]

• Up to 4.3 ng/mL (pregnancy) [37]

Estrone

• Up to 0.06 ng/mL (males) [24]

0.54%

Low

• Up to 0.2 ng/mL (females) [24]

Ethinyl estradiol

Up to 0.1 ng/mL while on medication [38–41]

0.23%

Low

Estriol

• Up to 18 ng/mL in pregnancy [42]

0.09%

Possible contribution in pregnancy

 

• Up to 2.4 ng/mL in non-pregnant females [43]

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