Giant osteoclasts in patients under bisphosphonates

BMC Clinical Pathology

Table 2 Histomorphometric parameters for patient 1 and 2

Parameters	Patient 1	Patient 2	Normal range
BV/TV (%)	37.3	22.3	21.9 ± 3.3
OV/BV (%)	0.6	0.6	2.0 ± 1.2
MAR (μm/j)	0.92	0.53	0.72 ± 0.12
MS/BS (%)	2.9	5.9	7.0 ± 4.1
MLT (j)	19.7	23.6	24.5 ± 7.5
BFR (μm3/μm²/j)	0.0267	0.0310	0.0435 ± 0.060
OcN/BA (cell/mm²)	3.44	8.91	3.80 ± 1.70
Oc S/BS (%)	3.1	2.8	1.4 ± 0.5

BV/TV: Bone volume/Tissue volume, OV/BV: Osteoid volume/Bone volume, MAR: Mineral Apposition Rate, MS/BS: Mineralizing surface/Bone surface, MLT: Mineralization Lag Time, BFR: Bone Formation Rate, OcN/BA: Osteoclasts number/Bone area, OcS/BS: Osteoclasts surface/Bone surface.
Note the absence of mineralization defect (normal MLT) in both patients and normal or increased OC number.

ISSN: 1472-6890