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Table 2 Histomorphometric parameters for patient 1 and 2

From: Giant osteoclasts in patients under bisphosphonates

Parameters Patient 1 Patient 2 Normal range
BV/TV (%) 37.3 22.3 21.9 ± 3.3
OV/BV (%) 0.6 0.6 2.0 ± 1.2
MAR (μm/j) 0.92 0.53 0.72 ± 0.12
MS/BS (%) 2.9 5.9 7.0 ± 4.1
MLT (j) 19.7 23.6 24.5 ± 7.5
BFR (μm3/μm2/j) 0.0267 0.0310 0.0435 ± 0.060
OcN/BA (cell/mm2) 3.44 8.91 3.80 ± 1.70
Oc S/BS (%) 3.1 2.8 1.4 ± 0.5
  1. BV/TV: Bone volume/Tissue volume, OV/BV: Osteoid volume/Bone volume, MAR: Mineral Apposition Rate, MS/BS: Mineralizing surface/Bone surface, MLT: Mineralization Lag Time, BFR: Bone Formation Rate, OcN/BA: Osteoclasts number/Bone area, OcS/BS: Osteoclasts surface/Bone surface.
  2. Note the absence of mineralization defect (normal MLT) in both patients and normal or increased OC number.