alphaB-crystallin is a marker of aggressive breast cancer behavior but does not independently predict for patient outcome: a combined analysis of two randomized studies

Table 1 Criteria of immunohistochemical evaluation

Protein	Scoring system	Cut-off	Staining pattern
ER	H-Score	≥1%	N
PgR	H-Score	≥1%	N
HER2	0-3	>10%	M
p53	SQ	>10%	N
Ki67	SQ	≥14%	N
EGFR	0-3	>1%	M
CK5	SQ	any	C
CK14	SQ	any	C
CK17	SQ	any	C
CK8/18	SQ	any	C
Vimentin	SQ	any	C
alphaB-crystallin	Neg, W, S	>30	C
BRCA1	H-Score	>100	N

H-Score, histoscore; N, nuclear; M, membranous; C, cytoplasmic; SQ, semi-quantitative; Neg, negative; W, weakly positive; S, strongly positive.

ISSN: 1472-6890