Figure 1

Study design. On postoperative day 0 (POD0), 6-millimeter diameter wounds were created in the central area of the ventral ear down to the perichondrium. On POD3, wounds were inoculated with either P. aeruginosa or K. pneumoniae (10⁶ CFU/wound). On POD 4, topical ciprofloxacin ointment was applied. Antimicrobial absorbent dressing changes were made on PODs 5, 6 and every second day until wound harvest. Wounds were harvested on PODs 4, 6 and 12 by excision using a 7-millimeter biopsy punch, and RNA was isolated for microarray analysis.