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Table 3 Chemotherapy utilization and health care cost outcomes

From: Diagnostic testing managed by hematopathology specialty and other laboratories: costs and patient diagnostic outcomes

 

Total

Genoptix

Large Labs

Other Controls

p-value

Study population size

(N = 24,664)

(N = 1,387)

(N = 4,162)

(N = 19,115)

 

Changes to chemotherapy

Within 30 days of starting chemotherapy

%

 

4.58%

6.68%

7.37%

0.91

Within 31–60 days of starting chemotherapy

%

 

1.78%

3.68%

5.12%

0.001

Adjusted odds ratio within 60 days of starting chemotherapy

Odds ratio

 

0.718

1.197

  

Confidence interval

0.472, 1.093

0.98, 1.463

P-value

0.1224

0.0784

 

Logistic model adjusted for age, region (Northwest, South), Medicare, initial diagnosis (MM, other NHL, other hematologic cancer/conditions), baseline Charlson comorbidity score, and baseline chemotherapy.

Testing paid cost PPPM - Post-index fixed 1-year Follow-up period

Bone marrow biopsy costs

Mean (SD)

$1,804.34 (12,424.61)

$149.54 (1,006.24)

$736.74 (5,638.49)

$2,156.87 (13,842.72)

<0.001

Bone marrow tests costs

Mean (SD)

$305.18 (596.83)

$1,130.03 (1,022.85)

$249.81 (383.29)

$257.39 (547.21)

<0.001

Other cancer-related tests costs

Mean (SD)

$292.68 (897.24)

$109.31 (405.88)

$199.39 (653.65)

$326.30 (963.49)

<0.001

Other hematological tests costs

Mean (SD)

$47.93 (258.88)

$20.97 (67.77)

$34.30 (184.72)

$52.85 (280.35)

<0.001

Total testing costs

Mean (SD)

$2,449.16 (12,689.30)

$1,409.84 (1,674.85)

$1,214.87 (5,842.95)

$2,793.32 14,127.97)

<0.001

Mean costs include individuals with zero costs

Mean healthcare costs PPPM during 1-year fixed follow-up period by Service type

Pharmacy cost

Mean (SD)

$624.69 (1,309.22)

$571.42 (1,279.36)

$578.84 (1,214.31)

$638.53 (1,330.84)

0.008

Medical costs

Mean (SD)

$8,556.06 (21,267.46)

$4,790.58 (9,286.12)

$5,830.33 (13,479.36)

$9,422.77 (23,117.31)

<0.001

Ambulatory cost

Mean (SD)

$3,279.69 (5,288.34)

$2,042.87 (3,618.11)

$2,759.93 (4,467.36)

$3,482.60 (5,529.99)

<0.001

Office costs

Mean (SD)

$1,370.38 (2,591.48)

$1,281.19 (2,468.00)

$1,516.33 (2,648.42)

$1,345.07 (2,586.69)

<0.001

Outpatient cost

Mean (SD)

$1,909.31 (4,338.71)

$761.68 (2,157.14)

$1,243.60 (3,251.64)

$2,137.53 (4,626.67)

<0.001

Emergency services cost

Mean (SD)

$54.10 (216.34)

$36.42 (120.02)

$40.09 (129.11)

$58.43 (235.87)

<0.001

Inpatient cost

Mean (SD)

$4,742.55 (19,060.20)

$1,515.11 (7,315.71)

$2,664.49 (11,325.53)

$5,429.20 (20,851.55)

<0.001

Other cost

Mean (SD)

$479.72 (2,746.48)

$1,196.18 (1,179.72)

$365.82 (1,200.40)

$452.54 (3,045.91)

<0.001

Total cost

Mean (SD)

$9,180.74 (21,433.97)

$5,362.00 (9,492.76)

$6,409.17 (13,676.32)

$10,061.30 (23,281.54)

<0.001

All-cause paid costs PPPM: Summary of multiple Regression model results

Paid costs-remainder year (excluding initial 30-day period)

Adjusted Costs

$6,019

$6,649

$7,801

 

Paid costs-1 year

Adjusted Costs

$8,202

$7,711

$10,302

 
 

GLM model, adjusting for gender, age, age2, region, final diagnosis, baseline Charlson comorbidity score, baseline chemotherapy, baseline radiation therapy, baseline inpatient stay, baseline number of bone marrow-related tests.

  1. Abbreviations: GLM generalized linear models, MM Multiple myeloma, NHL Non-Hodgkin’s lymphoma, PPPM Per-Patient-Per-Month, SD Standard deviation.