BMC Clinical Pathology

Table 3 Univariate analyses of disease progresssion (n =158)

From: Expression of histone deacetylases 1, 2 and 3 in urothelial bladder cancer

Variable	Categorization	Tumor progression
Variable	Categorization	n^a	events	p^b
*Pathologic data:*
Tumor stage (WHO 1973^c)
	pTa	85	10	0.412
	pT1	68	12
Histologic grade (WHO 1973^c)
	G1	43	3	0.093
	G2	82	12
	G3	28	7
Histologic grade (WHO 2004^d)
	Low grade	95	10	0.092
	High grade	58	12
Adjacent carcinoma in situ
	No	141	20	0.570
	Yes	12	2
Multifocality
	Unifocal tumor	111	15	0.486
	Multifocal tumor	42	7
Growth pattern
	Papillary	146	17	<0.0001
	Solid	7	5
*Immunohistochemistry:*
HDAC-1
	Low expression	92	9	0.085
	High expression	61	13
HDAC-2
	Low expression	88	12	0.628
	High expression	65	10
HDAC-3
	Low expression	65	8	0.754
	High expression	88	14
Ki-67 IHC
	Low expression	101	9	0.004
	High expression	52	13

^aOnly primary pTa and pT1 tumours are included.
^bLog Rank test (2-sided); bold face representing p-values <0.05.
^cStaging and grading according to the 1973 WHO classification system.
^dStaging and grading according to the 2004 WHO classification system.

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