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Table 2 Associations of the HDAC-1, -2 and 3 and Ki-67 with pathologic characteristics (n = 174)

From: Expression of histone deacetylases 1, 2 and 3 in urothelial bladder cancer

Variable

Categorization

HDAC-1 expression

HDAC-2 expression

HDAC-3 expression

Ki-67 expression

  

Low

High

p

Low

High

p

Low

High

p

Low

High

p

Tumor stage (WHO 1973)a

 

pTa

59

31

0.162

55

35

0.811

37

53

0.257

71

19

<0.001

 

pT1

37

31

 

37

31

 

30

38

 

35

33

 
 

pT2

5

8

 

7

6

 

2

11

 

2

11

 
 

pT3

2

0

 

1

1

 

1

1

 

0

2

 
 

pT4

1

0

 

1

0

 

1

0

 

0

1

 

Histologic grade (WHO 1973)a

 

G1

29

15

0.022

32

12

0.026

20

24

0.425

39

5

<0.001

 

G2

57

30

 

50

37

 

37

50

 

61

26

 
 

G3

18

25

 

19

24

 

14

29

 

8

35

 

Histologic grade (WHO 2004)b

 

Low grade

71

30

0.001

68

33

0.005

49

52

0.019

87

14

<0.001

 

High grade

33

40

 

33

40

 

22

51

 

21

52

 

Adjacent carcinoma in situb

 

No

96

62

0.432

96

62

0.032

65

93

1.00

105

53

<0.001

 

Yes

8

8

 

5

11

 

6

10

 

3

13

 

Multiplicityb

 

Solitary

79

45

0.124

77

47

0.093

49

75

0.587

86

38

0.003

 

Multifocal

25

25

 

24

26

 

22

28

 

22

28

 

Growth patternb

 

Papillary

97

62

0.278

94

65

0.416

65

94

1.00

107

52

<0.001

 

Solid

7

8

 

7

8

 

6

9

 

1

14

 
  1. aChi-Square Pearson (2-sided); bold face representing p-values < 0.05.
  2. bFisher’s exact test (2-sided); bold face representing p-values < 0.05.