Table 7 Results of Cox regression analysis summarizing prognostic factors in patients with soft tissue sarcomas
From: Prognostic impact of Skp2, ER and PGR in male and female patients with soft tissue sarcomas
All patients, N = 193 | Men, N = 81 | Women, N = 112 | |||||||
|---|---|---|---|---|---|---|---|---|---|
Factor | Hazard ratio | 95% CI | P | Hazard ratio | 95% CI | P | Hazard ratio | 95% CI | P |
Age | |||||||||
0–59 years | 1.00 | 1.00 | 1.00 | ||||||
≥60 years | 1.84 | 1.15-2.95 | 0.012 | 1.69 | 0.65-4.41 | 0.282 | 1.51 | 0.83-2.77 | 0.179 |
Nationality | |||||||||
Norwegian | 1.00 | 1.00 | 1.00 | ||||||
Russian | 1.49 | 0.88-2.52 | 0.143 | 1.39 | 0.41-4.66 | 0.598 | 2.51 | 1.20-5.21 | 0.014 |
Tumor size | |||||||||
<5 cm | 1.00 | 0.138* | 1.00 | 0.668* | 1.00 | 0.020* | |||
5–9 cm | 1.47 | 0.79-2.73 | 0.226 | 1.68 | 0.54-5.25 | 0.372 | 1.71 | 0.77-3.77 | 0.187 |
≥10 cm | 1.91 | 1.01-3.60 | 0.047 | 1.32 | 0.40-4.39 | 0.652 | 3.14 | 1.38-7.15 | 0.006 |
Malignancy grade FNCLCC | |||||||||
1 | 1.00 | <0.001* | 1.00 | <0.001 | 1.00 | 0.004* | |||
2 | 2.72 | 1.36-5.46 | 0.005 | 3.07 | 0.86-10.96 | 0.084 | 4.33 | 1.76-10.67 | 0.001 |
3 | 4.61 | 2.26-9.40 | <0.001 | 15.47 | 4.36-54.97 | <0.001 | 4.23 | 1.64-10.89 | 0.003 |
Resection margins | |||||||||
Wide | 1.00 | 1.00 | 1.00 | ||||||
Non-wide | 1.87 | 1.16-3.02 | 0.010 | 7.69 | 2.67-22.16 | <0.001 | 0.81 | 0.42-1.54 | 0.512 |
Skp2 | |||||||||
Low | 1.00 | 1.00 | 1.00 | ||||||
High | 1.48 | 0.87-2.52 | 0.151 | 0.46 | 0.19-1.12 | 0.088 | 2.52 | 1.31-4.85 | 0.006 |
ER / PGR | |||||||||
Low/low | 1.00 | 0.006* | 1.00 | 0.004* | 1.00 | 0.216* | |||
Low/high | 2.64 | 1.43-4.85 | 0.002 | 4.99 | 1.31-18.97 | 0.018 | 1.91 | 0.89-4.11 | 0.097 |
High/low | 2.07 | 1.15-3.73 | 0.015 | 8.35 | 2.55-27.36 | <0.001 | 1.76 | 0.79-3.93 | 0.170 |
High/high | 1.16 | 0.57-2.38 | 0.682 | 4.50 | 0.96-21.13 | 0.056 | 0.92 | 0.36-2.35 | 0.868 |