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Table 2 Univariate and multivariate analyses of immunohistochemical parameters (disease-free survival and overall survival)

From: A simple immunohistochemical panel comprising 2 conventional markers, Ki67 and p53, is a powerful tool for predicting patient outcome in luminal-type breast cancer

   Univariate Multivariate
   Total (n=142) Hazard ratio (95% CI) P-value Hazard ratio (95% CI) P-value
Disease-free survival         
Ki67 LI Low 98 1    1   
  High 44 3.6 1.7-7.9 0.0010 3.2 1.4-7.6 0.0073
p53 Negative 122 1    1   
  Positive 20 5.2 2.3-11.9 <0.0001 3.9 1.6-9.4 0.0025
FOXA1 Low 20 1    1   
  High 119 1.4 0.51-3.6 0.54 1.7 0.56-5.2 0.34
GATA3 Negative 30 1    1   
  Positive 112 1.5 0.65-3.5 0.34 1.2 0.46-3.4 0.66
Basal phenotype marker Negative 133 1    1   
(CK5/6, CK14, EGFR) Positive 9 1.0 0.24-4.3 0.98 0.47 0.10-2.2 0.34
P-cadherin Low 90 1    1   
  High 52 1.3 0.59-2.8 0.52 0.87 0.37-2.1 0.75
Overall survival         
Ki67 LI Low 98 1    1   
  High 44 4.4 1.3-14.6 0.016 3.2 0.91-11.9 0.070
p53 Negative 122 1    1   
  Positive 20 5.7 1.8-18.0 0.0029 3.8 1.1-13.0 0.030
FOXA1 Low 20 1    1   
  High 119 0.49 0.06-3.9 0.50 0.75 0.07-7.5 0.81
GATA3 Negative 30 1    1   
  Positive 112 1.1 0.31-4.3 0.84 1.3 0.29-6.1 0.70
Basal phenotype marker Negative 133 1    1   
(CK5/6, CK14, EGFR) Positive 9 1.2 0.15-9.3 0.86 0.60 0.07-5.4 0.64
P-cadherin Low 90 1    1   
  High 52 1.8 0.57-5.5 0.32 1.2 0.36-4.2 0.73
  1. Abbreviation: 95% CI 95% confidence interval, LI labeling index.