Table 2 Univariate and multivariate analyses of immunohistochemical parameters (disease-free survival and overall survival)
Univariate | Multivariate | |||||||
|---|---|---|---|---|---|---|---|---|
Total (n=142) | Hazard ratio | (95% CI) | P-value | Hazard ratio | (95% CI) | P-value | ||
Disease-free survival | ||||||||
Ki67 LI | Low | 98 | 1 | 1 | ||||
High | 44 | 3.6 | 1.7-7.9 | 0.0010 | 3.2 | 1.4-7.6 | 0.0073 | |
p53 | Negative | 122 | 1 | 1 | ||||
Positive | 20 | 5.2 | 2.3-11.9 | <0.0001 | 3.9 | 1.6-9.4 | 0.0025 | |
FOXA1 | Low | 20 | 1 | 1 | ||||
High | 119 | 1.4 | 0.51-3.6 | 0.54 | 1.7 | 0.56-5.2 | 0.34 | |
GATA3 | Negative | 30 | 1 | 1 | ||||
Positive | 112 | 1.5 | 0.65-3.5 | 0.34 | 1.2 | 0.46-3.4 | 0.66 | |
Basal phenotype marker | Negative | 133 | 1 | 1 | ||||
(CK5/6, CK14, EGFR) | Positive | 9 | 1.0 | 0.24-4.3 | 0.98 | 0.47 | 0.10-2.2 | 0.34 |
P-cadherin | Low | 90 | 1 | 1 | ||||
High | 52 | 1.3 | 0.59-2.8 | 0.52 | 0.87 | 0.37-2.1 | 0.75 | |
Overall survival | ||||||||
Ki67 LI | Low | 98 | 1 | 1 | ||||
High | 44 | 4.4 | 1.3-14.6 | 0.016 | 3.2 | 0.91-11.9 | 0.070 | |
p53 | Negative | 122 | 1 | 1 | ||||
Positive | 20 | 5.7 | 1.8-18.0 | 0.0029 | 3.8 | 1.1-13.0 | 0.030 | |
FOXA1 | Low | 20 | 1 | 1 | ||||
High | 119 | 0.49 | 0.06-3.9 | 0.50 | 0.75 | 0.07-7.5 | 0.81 | |
GATA3 | Negative | 30 | 1 | 1 | ||||
Positive | 112 | 1.1 | 0.31-4.3 | 0.84 | 1.3 | 0.29-6.1 | 0.70 | |
Basal phenotype marker | Negative | 133 | 1 | 1 | ||||
(CK5/6, CK14, EGFR) | Positive | 9 | 1.2 | 0.15-9.3 | 0.86 | 0.60 | 0.07-5.4 | 0.64 |
P-cadherin | Low | 90 | 1 | 1 | ||||
High | 52 | 1.8 | 0.57-5.5 | 0.32 | 1.2 | 0.36-4.2 | 0.73 | |