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Figure 2 | BMC Clinical Pathology

Figure 2

From: 13-year-old tuberous sclerosis patient with renal cell carcinoma associated with multiple renal angiomyolipomas developing multifocal micronodular pneumocyte hyperplasia

Figure 2

Morphology of pulmonary lesions. Axial (A) computer tomography (CT) of the chest revealed multiple soft tissue density nodules of 1–6 mm in diameter in both lungs with a minimal peripheral ground glass component in a random peribronchovascular-centrilobular distribution pattern. There was slight size predominance in the lower lung zones with the largest nodules being located in the middle and lower lobes. Furthermore, there was moderate regional air trapping in the basal lower lobes. Histologically and immunohistologically, nodules were composed of proliferated and enlarged type II pneumocytes (B, x40 /C, E, G x100) expressing pan-CK (E, x100), TTF-1 (F, x100) with low proliferation rate in Ki67 (H, x100).

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