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Table 3 Performance of the different prediction models for MMR (n = 200)

From: Efficient and reproducible identification of mismatch repair deficient colon cancer: validation of the MMR index and comparison with other predictive models

Model

Sensitivity (%)

Specificity (%)

PPV (%)

NPV (%)

AUC

MMR index

97.5

68.8

44.3

99.1

0.83

4 features present

     

PREDICT

95.0

66.3

41.3

98.2

0.81

Score ≥2.5

     

Simplified PREDICT

95.0

65.0

40.4

98.1

0.80

2 features present

     

MsPath

100.0

40.6

29.6

100.0

0.70

Score ≥1

     

MSI probability score

100.0

45.6

31.5

100.0

0.73

Score ≥1

97.5

56.3

35.8

98.9

0.77

Score ≥1.5

     

RERtest6

60.0

99.4

96.0

90.8

0.80

Score <0.8

     
  1. Abbreviations: AUC area under curve, MMR mismatch repair, MSI microsatellite instability, NPV negative predictive value, PPV positive predictive value.