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Table 3 Score summary of the analysed cohort

From: An observational study on the expression levels of MDM2 and MDMX proteins, and associated effects on P53 in a series of human liposarcomas

 

MDMX -

MDMX +

MDMX ++

Total

 

P53 -

P53 +

P53 -

P53 +

P53 -

P53 +

MDM2 -

9*

2*

0

0

0

0

11

MDM2 +

3

1

4

0

0

2†

10

MDM2 ++

4§

0

12§

1§

3†

20†

40

Total

19

17

25

61

  1. Immunohistochemistry scores for MDM2 and MDMX were stratified as follows: (-) normal expression: when <11% of cells had positive nuclear staining; (+) moderate over-expression: when 11 – 40% of cells had positive nuclear staining; (++) strong over-expression: when >40% of cells had positive nuclear staining. Scores for P53 were: (-) negative expression: when ≤10% of cells had positive nuclear staining; (+) positive expression: when 11% or more of cells had positive nuclear staining.
  2. *MDM-P53 pathway is inactive as negative staining for MDM2 and MDMX; § collaborative MDM2 and MDMX pattern with higher MDM2 expression levels resulting in negative P53; † competitive MDM2 and MDMX pattern where comparable levels of MDM2 and MDMX expression lead to positive P53.