|     Univariate survival analysis |     Multivariate survival analysis | ||
---|---|---|---|---|
 |      Cancer-specific survival |      Cancer-specific survival | ||
 |    Hazard ratio | P-value |    Hazard ratio | P-value |
 |     (95% CI) |  |     (95% CI) |  |
Age (<50/>50Â years) | 0.78 (0.42-1.47 | 0.448 | Â | Â |
Size (≤20/21-50/>50 mm) | 2.19 (1.14-4.22) | 0.018 |  | 0.116 |
Grade (I/II/III) | 1.30 (0.63-2.72) | 0.478 | Â | Â |
Involved lymph node (0/1-3/>3) | 1.85 (1.24-2.66) | 0.001 | 1.71 (1.17-2.50) | 0.006 |
Progesterone -receptor status (PR-/PR+) | 0.05 (0.00-22.73) | 0.330 | Â | Â |
HER-2 status (HER-2 -/HER-2+) | 1.26 (0.66-2.41) | 0.489 | Â | Â |
Ki-67 status (Low Ki-67/High Ki-67) | 1.48 (0.70-3.11) | 0.305 | Â | Â |
LVI (Absent/Present) | 2.14 (1.08-4.22) | 0.029 | Â | 0.428 |
MVD (CD34+) (tertiles 1, 2, 3) | 1.62 (1.08-2.44) | 0.021 | Â | 0.130 |
Loco-regional treatment (Lumpectomy + radiotherapy/mastectomy + radiotherapy) | 3.27 (1.44-7.42) | 0.005 | 2.64 (1.14-6.09) | 0.023 |
Systemic treatment (ER-based treatment) (hormonal/hormonal + chemotherapy/chemotherapy/none) | 1.00 (0.70-1.42) | 1.00 |  |  |