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Table 1 Clinical characteristics of 54 patients a in relation to immunohistochemical staining for GAPDH, PKM2 and ATP5B

From: Metabolic markers GAPDH, PKM2, ATP5B and BEC-index in advanced serous ovarian cancer

  GAPDH PKM2 ATP5B
n= 54 n= 54 n= 54
Characteristic low <50% 2+ high ≥50% 2+ low <20% 3+ high ≥20% 3+ low 1-2+ high 3+
n = 26 n = 28 n = 26 n = 28 n = 26 n = 28
N (%) N (%) N (%) N (%) N (%) N (%)
Age at diagnosis (years)       
  Median 64.5 (39–83) NA NA NA NA NA NA
Diagnosis       
  Epithelial ovarian ( n = 41) 22 (54) 19 (46) 23 (56) 18 (44) 21 (51) 20 (49)
  Fallopian tube ( n = 10) 4 (40) 6 (60) 4 (40) 6 (60) 4 (40) 6 (60)
  Peritoneal ( n = 3) 0 3 (100) 0 3 (100) 1 (33) 2 (67)
FIGO stage       
  IIC ( n = 2) - IIIB ( n = 3) 2 (40) 3 (60) 1 (20) 4 (80) 5 (100) 0
  IIIC ( n = 42) 21 (50) 21 (50) 21 (50) 21 (50) 18 (43) 24 (57)
  IV ( n = 7) 3 (43) 4 (57) 4 (57) 3 (43) 3 (43) 4 (57)
Subtype       
  Serous ( n = 47) 22 (47) 25 (53) 19 (40) 28 (60) 23 (49) 24 (51)
  Endometrioid ( n = 7) 4 (57) 3 (43) 7 (100) 0 3 (43) 4 (57)
Grade of differentiation b       
  High ( n = 4) 2 (50) 2 (50) 1 (25) 3 (75) 2 (50) 2 (50)
  Moderate ( n = 4) 2 (50) 2 (50) 2 (50) 2 (50) 2 (50) 2 (50)
  Poor ( n = 46) 22 (48) 24 (52) 23 (50) 23 (50) 22 (48) 24 (52)
Postop residual tumor size       
  0 mm ( n = 6) 3 (50) 3 (50) 0 6 (100) 4 (67) 2 (33)
  1-10 mm ( n = 10) 4 (40) 6 (60) 3 (30) 7 (70) 5 (50) 5 (50)
  >10 mm ( n = 38) 19 (50) 19 (50) 23 (61) 15 (39) 17 (45) 21 (55)
1 st line Chemotherapy       
  Carboplatin + paclitaxel ( n = 47) NA NA NA NA NA NA
  Other platinum based ( n = 7)       
Time from EOT to recurrence/progression       
  < 6 months ( n = 25) 10 (40) 15 (60) 13 (52) 12 (48) 8 (32) 17 (68)
  ≥ 6 months ( n = 28) 16 (57) 12 (43) 13 (46) 15 (54) 17 (61) 11 (39)
  Unknown ( n = 1) 0 1 (100) 0 1 (100) 1 (100) 0
Survival       
  Alive, no evidence of disease ( n = 8) 4 (50) 4 (50) 2 (25) 6 (75) 6 (75) 2 (25)
  Alive, with disease ( n = 9) 6 (67) 3 (33) 4 (44) 5 (56) 5 (56) 4 (44)
  Death from disease ( n = 36) 16 (44) 20 (56) 19 (53) 17 (47) 14 (39) 22 (61)
  Death from other cause ( n = 1) 0 1 (100) 1 (100) 0 1 (100) 0
  1. Abbreviations: FIGO, Federation Internationale de Gynecologie et d’Obstetrique, EOT, End of treatment, NA, Not applicable.
  2. aTumor blocks could be retrieved in 54 of 56 cases.
  3. bGrade of differentiation according to WHO international histological classification of tumors.