Pepsinogen I and II expressions in situ and their correlations with serum pesignogen levels in gastric cancer and its precancerous disease

Table 2 In situ expression of PGs in different sex, age and H. pylori status

	Total		NOR		GS		GA
	IRS score^a		IRS score^a		IRS score^a		IRS score^a
In situ PGI staining
Sex		0.265		0.002		0.599		0.964
Female	4.0(2.0,7.0)		5.0(4.0,7.5)		6.0(4.0,9.0)		2.0(1.0,3.3)
Male	3.0(0.0,7.0)		9.0(7.0,10.5)		6.0(2.5,8.5)		2.0(1.0,3.0)
Age(years)		0.003		0.681		0.183		0.563
<50	4.0(2.0,9.0)		7.5(5.5,9.3)		7.0(3.0,10.0)		2.0(1.0,4.0)
≥50	3.0(0.0,6.0)		7.5(5.0,10.8)		5.0(3.0,7.0)		2.0(1.0,3.0)
H. pylori IgG		0.359		/		0.515		0.659
EIU < 34	3.0(1.0,6.0)		7.5(5.0,10.0)		5.0(3.0,9.3)		2.0(1.0,3.0)
EIU ≥ 34	2.0(0.0,6.0)		/		6.0(4.0,8.8)		2.0(1.0,3.5)
In situ PGII staining
Sex		0.073		0.363		0.245		0.643
Female	3.0(1.0,7.0)		7.0(4.5,11.0)		6.0(4.0,9.0)		3.0(1.0,5.0)
Male	5.0(2.0,7.0)		9.0(7.5,10.0)		5.0(3.0,9.0)		2.0(1.3,4.0)
Age(years)		0.003		0.198		0.260		0.173
<50	5.0(2.0,9.0)		7.5(4.0,9.0)		6.5(3.3,9.8)		3.0(2.0,5.8)
≥50	3.0(0.0,6.3)		9.5(6.0,11.0)		5.0(2.0,8.0)		2.0(1.0,4.0)
H. pylori IgG		0.942		/		0.344		0.069
EIU < 34	3.0(1.0,6.0)		8.5(5.8,10.3)		6.0(2.0,9.0)		2.0(1.0,3.0)
EIU ≥ 34	3.0(0.0,6.0)		/		5.5(4.0,9.8)		3.0(2.0,5.5)
In situ PGI/PGII staining
Sex		0.453		0.123		1.000		0.650
Female	0.8(0.4,1.3)		0.8(0.5,1.0)		1.0(0.7,1.5)		0.6(0.2,1.2)
Male	0.8(0.0,1.1)		1.0(0.8,1.2)		1.0(0.7,1.5)		0.8(0.4,1.0)
Age(years)		0.011		0.530		0.864		0.462
<50	1.0(0.6,1.3)		1.0(0.6,1.6)		1.0(0.7,1.4)		1.0(0.4,1.0)
≥50	0.7(0.0,1.0)		01.0(0.8,1.0)		1.0(0.7,1.5)		0.7(0.1,1.0)
H. pylori IgG		0.062		/		0.763		0.599
EIU < 34	0.9(0.3,1.4)		1.0(0.7,1.1)		1.0(0.7,1.5)		0.8(0.2,2.5)
EIU ≥ 34	0.6(0.0,1.0)		/		1.0(0.7,1.4)		0.7(0.4,1.0)

^a, IRS of PGI, PGII and PGI/II ratio were represented as median (25%, 75%); ^b, in situ expression of PGI, PGII, PGI/II ratio between two groups were compared by Mann–Whitney test. Analyses results with P < 0.05 were highlighted in bold characters.

ISSN: 1472-6890