Figure 1

Immunostaining for EphA2, EphA4, and ephrinA1. Representative normal gastric epithelium and stromal cells showing no or weak immunostaining for EphA2 (A), EphA4 (B), and ephrinA1 (C). Representative primary gastric carcinomas showing immunostaining for EphA2 with intensity scores of 1 (D), 2 (E), and 3 (F), immunostaining for EphA4 with intensity scores of 1 (G), 2 (H), and 3 (I), and immunostaining for ephrinA1 with intensity scores of 0 (J) and 3 (K). Positive control for ephrinA1 in breast cancer tissue is shown (L). Representative metastatic lymph nodes showing immunostaining for EphA2 (M), EphA4 (N), and ephrinA1 (O). Magnification, 400× (A-L), 200× (M-O), Heterogeneous staining of EphA4 in one tumor (P); magnification, 20×. The upper and lower insets show EphA4 with intensity scores of 1 and 3, respectively; magnification, 200 × .