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Table 1 Histological features of 27802 cases from 1990 to 2009

From: Central nervous system tumors: a single center pathology review of 34,140 cases over 60 years

 

N (%)

M

F

Ma(yrs)

Ma(yrs)

I. Tumors of neuroepithelial tissue

  1. Astrocytic tumors

   Pilocytic astrocytoma

469 (1.69)

253

214

21.1

17

   Pilomyxoid astrocytoma

20 (0.07)

8

12

19.2

17

   Subependymal giant cell astrocytoma

27 (0.10)

15

12

16.2

13

   Pleomorphic xanthoastrocytoma

67 (0.24)

33

34

28.4

23

   Glioblastoma

2170 (7.81)

1362

805

50.2

53

   Giant cell glioblastoma

12 (0.04)

9

3

42.7

41

   Gliosarcoma

64 (0.23)

39

25

48.8

50.5

   Anaplastic astrocytoma

939 (3.38)

593

346

49.2

42

   Gliomatosis cerebri

3 (0.01)

2

1

59

62

  2. Oligodendroglial tumors

   Oligodendroglioma

990 (3.56)

555

426

38.6

39

   Anaplastic oligodendrogliom

534 (1.92)

313

221

43.5

44

  3. Oligoastrocytic tumors

   Oligoastrocytoma

243 (0.87)

143

100

38.9

39

   Anaplastic oligoastrocytoma

89 (0.32)

56

33

44.7

46

  4. Ependymal tumors

   Ependymoma

623 (2.24)

350

273

37

38

   Subependymoma

39 (0.14)

21

18

43

43

   Anaplastic ependymoma

223 (0.80)

129

93

30

30

  5. Choroid plexus tumor

   Choroid plexus papilloma

91 (0.33)

34

57

29

29

   Atypical choroid plexus papilloma

2 (0.01)

0

2

37.5

37.5

   Choroid plexus carcinoma

11 (0.04)

8

3

31.6

25

  6. Other neuroepithelial tumors

   Chordoid glioma of the third ventricle

3 (0.01)

1

2

31.3

27

   Astroblastoma

4 (0.01)

2

2

37.8

42

  7. Neuronal and mixed neuronal-glial tumors

   Cerebellar liponeurocytoma

1 (0.00)

1

0

59

59

   Desmoplastic infantile astrocytoma/ganglioglioma

5 (0.02)

1

4

16.8

11

   Dysembryoplastic neuroepithelial tumor

54 (0.19)

34

20

22.6

17.5

   Dysplastic gangliocytoma of cerebellum, Lhermitte-Duclos

7 (0.03)

3

4

28.7

38

   Rosette-forming glioneuronal tumor of the fourth ventricle

4 (0.01)

0

4

28.3

24

   Paraganglioma

29 (0.10)

14

15

42.5

42

   Papillary glioneuronal tumor

13 (0.05)

9

4

32.4

29

   Anaplastic ganglioglioma

43 (0.15)

26

17

39.7

41

   Gangliocytoma

40 (0.14)

29

11

29.6

31.5

   Ganglioglioma

137 (0.49)

87

49

33.1

32

   Central neurocytoma

131 (0.47)

63

68

30.2

29

  8. Tumors of pineal region

   Papillary tumor of the pineal region

2 (0.01)

1

1

31.5

31.5

   Pineocytoma

15 (0.05)

5

10

30.3

22

   Pineal parenchymal tumor of intermediate differentiation

5 (0.02)

5

0

26.8

20

   Pineoblastoma

10 (0.04)

5

5

25.6

17.5

  9. Embryonal tumors

   Medulloblastoma

515 (1.85)

329

183

15.4

12

   PNET

119 (0.43)

75

43

21.9

17

   Atypical teratoid/rhabdoid tumor

4 (0.01)

2

2

21.8

23

II. Tumors of cranial and paraspinal nerves

  1. Schwannoma (neurilemoma, neurinoma)

3499 (12.59)

1754

1736

45

45

  2. Neurofibroma

166 (0.60)

106

60

36.3

38

  3. Perineurioma

1 (0.00)

0

1

69

69

  4. MPNST

26 (0.09)

11

15

37.8

42

III. Tumors of meninges

  1. Tumors of meningothelial cells

   Grade I meningothelial cells tumors

7623 (27.42)

2294

5309

50.7

51

   Atypical

359 (1.29)

184

173

51.2

52

   Chordoid

16 (0.06)

8

8

48.5

51

   Clear cell

30 (0.11)

13

17

37.5

39.5

   Papillary

26 (0.09)

16

10

36.7

35.5

   Rhabdoid

15 (0.05)

9

6

42.2

42

   Anaplastic, malignant

235 (0.85)

129

105

50.3

50

  2. Mesenchymal tumors

   Hemangiopericytoma

202 (0.73)

112

88

43.3

42

   Anaplstic hemangiopericytoma

8 (0.03)

5

3

48.3

45.5

   Other Mesenchymal tumors

825 (2.97)

450

369

36

37

  3. Primarymelanocytic lesions

   Diffuse melanocytosis

2 (0.01)

1

1

35.5

35.5

   Melanocytoma

9 (0.03)

5

4

47

47

   Malignantmelanoma

31 (0.11)

21

10

42.2

42

  4. Other neoplasms related to the meninges

   Hemangioblastoma

760 (2.73)

463

293

40.8

40

IV. Lymphomas and hematopoietic neoplasms

464 (1.67)

272

191

49.7

52

V. Germ cell tumors

  1. Germinoma

204 (0.73)

148

56

17.4

16

  2. Embryonal carcinoma

14 (0.05)

12

2

12.2

12.5

  3. Yolk sac tumor

2 (0.01)

2

0

7

7

  4. Choriocarcinoma

1 (0.00)

0

1

34

34

  5. Teratoma

10 (0.04)

8

2

14.5

14

   Mature

56 (0.20)

36

20

23.5

20.5

   Immature

22 (0.08)

20

2

16

14.5

   With malignant transformation

4 (0.01)

4

0

13.3

14

  6. Mixed germ cell tumors

35 (0.13)

29

6

16.6

14

VI. Tumors of the sellar region

   Craniopharyngioma

1144 (4.11)

665

477

32.1

33

   Granular cell tumor

7 (0.03)

2

5

49

52

   Pituicytoma

1 (0.00)

1

0

45

45

   Spindle cell oncocytoma of the adenohypophysis

1 (0.00)

1

0

24

24

VII. Metastatic tumors

1431 (5.15)

890

536

53.9

55

Total

27802

13945

13774

  
  1. N = Number; M = Male; F = Female;
  2. Ma = Median age at diagnosis; ma = Mean age at diagnosis;
  3. PNET = Primitive neuroectodermal tumor;
  4. Grade I meningothelial cells tumors = Meningiothelial; Fibrous, fibroblastic; Transitional, mixed; Psammomatous; Angiomatous; Microcystic; Secretory; Lymphop lasmacyte-rich; Metaplastic.
  5. Other mesenchymal tumors = Lipoma; Angiolipoma; Hibernoma; Liposarcoma; Solitary fibrous tumor; Fibrosarcoma; Malignant fibrous histiocytoma; Leiomyoma; Leiomyosarcoma; Rhabdomyoma; Rhabdomyosarcoma; Chondroma; Chondrosarcoma; Osteoma; Osteosarcoma; Osteochondroma; Hemangioma; Angiosarcoma; Kaposi sarcoma; Ewing sarcoma-PNET.
  6. MPNST = Malignant peripheral nerve sheath tumor.
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BMC Clinical Pathology

ISSN: 1472-6890

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