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Table 3 Overall concordance analysis between manual and automated HER2 for three categorical HER2 /CEP17 FISH parameters

From: Comparison of automated and manual FISH for evaluation of HER2 gene status on breast carcinoma core biopsies

 

Manual HER2 FISH (%)

Automated HER2 FISH (%)

Pearson chi2coefficient

P value

Concordance rate (%)

Cohen’s kappa

HER2 genetic heterogeneity

Present (5-50% carcinoma cells with HER2/CEP17 ratio >2.2)

17

14

18.59

< 0.001

85

0.428

 Absent

83

86

HER2 cluster

 Present (HER2 cluster in >1% cells)

41

39

76.71

< 0.001

94

0.875

 Absent

59

61

CEP17 polyploidy

 Present (Chr. 17 copy number >3.00)

4

12

15.66

< 0.001

90

0.335

 Absent

96

88