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Table 2 Average of thickness and intensity of immunohistochemical staining signal for the different cellular proteins in each morphological class

From: Cell culture model predicts human disease: Altered expression of junction proteins and matrix metalloproteinases in cervical dysplasia

 

p16

MMP-7

MMP-16

CK8/18

Laminin

E-cadherin

b-catenin

 

th

int

th

int

th

int

th

int

th

int

th

int

th

int

Normal SE

0

0

1

1

1-2

1

0

0

0

0

1-2

2

1-2

2

Condyloma

0

0

1–2

1–2

2

1

0–1

2

0

0

2–3

2–3

2–3

2

CIN1

1–2

1–2

1–2

1–2

2–3

1–2

0–1

1–2

0–1

1

2–3

2–3

2–3

2–3

CIN2

1–2

2

1–2

1–2

2–3

1–2

0–1

1–2

0–1

1

2–3

2–3

2–3

2–3

CIN3

1–2

3

1–2

1–2

2–3

2–3

1

1

1–2

1

3

3

2–3

2–3

Normal CE

n.a.

0

n.a.

1

n.a.

1

n.a.

1-2

n.a.

0

n.a.

1

n.a.

1

AIS

3

3

0–1

1

1–2

1–2

0–1

1

0–1

1

3

3

2

2–3

  1. Thickness (th) and intensity (int) of staining are evaluated in a scale from 0 (no staining) to 3 (full thickness of epithelium or very intense staining). Normal SE, normal squamous epithelium. Normal CE, normal columnar epithelium. b-catenin = beta-catenin. n.a., not applicable due to single layer nature of normal columnar epithelium.
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BMC Clinical Pathology

ISSN: 1472-6890

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