Prognostic impact of CD57, CD68, M-CSF, CSF-1R, Ki67 and TGF-beta in soft tissue sarcomas

BMC Clinical Pathology

Table 6 Results of Cox regression analysis summarizing significant independent prognostic factors in patients with soft tissue sarcomas

	Tumor, N=249			Capsule, N=80
Factor	Hazard Ratio	95% CI	P	Hazard Ratio	95% CI	P
Nationality
Norwegian	1.000			1.000
Russian	0.948	0.603-1.490	0.816	0.588	0.263-1.312	0.194
Tumor size
< 5 cm	1.000		0.540*	1.000		0.342*
5-10 cm	1.103	0.687-1.770	0.685	0.888	0.376-2.099
> 10 cm	1.310	0.797-2.153	0.287	1.671	0.660-4.233
Malignancy grade FNCLCC
1	1.000		0.001*	1.000		0.051*
2	1.997	1.129-3.531	0.017	1.402	0.383-5.137	0.610
3	2.874	1.617-5.107	<0.001	2.954	0.837-10.432	0.092
Metastasis at time of diagnosis
No	1.000			1.000
Yes	2.842	1.855-4.354	<0.001	2.101	0.901-4.898	0.086
Resection margins
Wide	1.000			1.000
Non-wide	2.523	1.706-3.730	<0.001	2.245	1.077-4-680	0.031
Ki67
Low	1.000		0.432*	1.000
Medium	1.059	0.528-2.163	0.876	-	-	-
High	1.365	0.710-2.625	0.351	2.553	1.167-5.584	0.019
M-CSF
Low	1.000			NIA
High	0.815	0.463-1.435	0.478
TGF-beta
Low	1.000			NIA
High	0.682	0.247-1.881	0.460
M-CSF and TGF-beta
Low	1.000			NIA
High	1.532	1.062-2.208	0.022

ISSN: 1472-6890