Evaluation of chemiluminescence, toluidine blue and histopathology for detection of high risk oral precancerous lesions: A cross-sectional study

Table 2 Diagnostic performance of the tests for high-risk lesions

Protocol	Parameter	Compared to HPMV	Using LCA
CHEM	Sensitivity	1.00 (0.82-1.00)	1.00 (0.99-1.00)
	Specificity	0.01 (0.00-0.06)	0.01 (0.00-0.04)
TBLU	Sensitivity	0.59 (0.36-0.78)	0.99 (0.92-1.00)
	Specificity	0.79 (0.69-0.87)	1.00 (0.99-1.00)
CHTB	Sensitivity	0.59 (0.36-0.78)	1.00 (0.99-1.00)
	Specificity	0.78 (0.68-0.86)	1.00 (0.99-1.00)
HPMV	Sensitivity	---	0.37 (0.19-0.55)
	Specificity	---	0.90 (0.83-0.97)
Prevalence of HRL		0.17 (0.10-0.24)	0.27 (0.18-0.36)

CHEM, chemiluminescence; TBLU, toluidine blue retention; CHTB, toluidine blue retention and chemiluminescence; HPMV, histopathology majority vote; LCA, latent class analysis; HRL, high risk lesion

ISSN: 1472-6890