Prognostic impact of peritumoral lymphocyte infiltration in soft tissue sarcomas

BMC Clinical Pathology

Table 1 Clinicopathologic variables and surival.

Characteristic	Patients (n)	Patients (%)	Median survival (months)	5-Year survival (%)	P
Age
≤ 20 years	7	9	NR	57	0.479
21-60 years	36	45	63	53
> 60 years	37	46	36	44
Sex
Male	35	44	63	50	0.847
Female	45	56	57	49
Nationality
Norwegian	59	74	38	48	0.646
Russian	21	26	127	52
Histology
Undifferentiated pleomorphic sarcoma	20	25	127	57	0.025
Leiomyosarcoma	21	26	67	52
Angiosarcoma	7	9	15	29
Liposarcoma	6	8	36	50
Rhabdomyosarcoma	6	8	32	50
Synovial sarcoma	6	8	31	50
MPNST	5	6	NR	80
MF/MFT	4	5	15	50
Other STS	5	6	11	0
Tumor localization
Extremities	31	39	123	61	0.447
Trunk	15	19	32	47
Retroperitoneum	11	14	57	42
Head/Neck	5	6	15	20
Pelvis	18	23	22	41
Tumor size
≤ 5 cm	26	33	67	54	0.800
5-10 cm	33	41	31	45
> 10 cm	20	25	80	53
Missing	1	1
Malignancy grade FNCLCC
1	15	19	NR	70	0.007
2	31	39	80	61
3	34	43	15	29
Tumor depth
Superficial	4	5	NR	100	0.046
Deep	76	95	32	46
Operated
Yes	73	91	75	54	< 0.001
No	7	9	5	0
Surgical margins
Wide	39	49	NR	67	< 0.001
Non-wide	41	51	18	32
Metastasis at diagnosis
No	65	81	80	57	< 0.001
Yes	15	19	11	14
Chemotherapy
No	59	74	36	46	0.147
Yes	21	26	NR	57
Radiotherapy
No	60	75	38	47	0.775
Yes	20	25	63	55

Prognostic clinicopathologic variables as predictors for disease-specific survival in soft tissue sarcomas with peritumoral capsule (univariate analysis, log rank test), N = 80 Abbreviations: MF/MFT, malignant fibroblastic/myofibroblastic tumors; MPNST, malignant peripheral nerve sheath tumor; STS, soft tissue sarcomas; NR, not reached Ninety-one percent (n = 73) underwent surgery. The 5-year survival with non-wide resection margins was 32% and with wide resection margins it was 67%.

ISSN: 1472-6890