Dual color chromogenic in situ hybridization for determination of HER2 status in breast cancer: a large comparative study to current state of the art fluorescence in situ hybridization

Table 5 Mean HER2/CEN-17 ratio and signal numbers for all specimens.

Signal copy numbers were normalized to 20 nuclei
a) Significant different from CISH ratio in a two tailed, paired t-test (N = 348, P < 0.001)
b) Significant different from CISH ratio in a two tailed, paired t-test (N = 350, P = 0.001)
c) Not significant different from CISH HER2 signals in a two tailed, paired t-test (N = 348, P = 0.245)
d) Not significant different from CISH HER2 signals in a two-tailed, paired t-test (N = 350, P = 0.284)
e) Significant different from CISH CEN-17 signals in a two tailed, paired t-test (N = 348, P < 0.001)
f) Significant different from CISH CEN-17 signals in a two-tailed, paired t-test (N = 350, P < 0.003)

ISSN: 1472-6890