Dual color chromogenic in situ hybridization for determination of HER2 status in breast cancer: a large comparative study to current state of the art fluorescence in situ hybridization

Table 4 Cross tabulation of HER2 gene status for CISH versus PathVysion FISH.

Two tailed 95% confidence intervals are based on the binomial distribution. Overall agreement: (342/350 × 100) = 97.7% (CI95: 95.7%; 98.9%), Positive agreement: (40/44 × 100) = 90.9% (CI95: 79.8%; 96.9%), Negative agreement: (302/306 × 100) = 98.7% (CI95: 96.9%; 99.6%) and Kappa: 0.90 (SE: 0.04)

ISSN: 1472-6890