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Table 2 Relationship between the response to neoadjuvant CRT and the expression of Bax, Bcl-2, Cytochrome-c, Caspase-3, VEGF, and MMP-9

From: Low Mmp 9 and VEGF levels predict good oncologic outcome in mid and low rectal cancer patients with neoadjuvant chemoradiation

 

Complete response (PCR)

Partial or no response (noPCR)

p value

Bax

   

<10%

1 (14)

18 (82)

0.003

>10%

6 (86)

4 (18)

 

Bcl-2

   

<10%

4 (57)

10 (45)

0.59

>10%

3 (43)

12 (55)

 

Cytochrome-c

68.38 ± 54.59

54.48 ± 28.85

0.4

Caspase-3

0.22 ± 0.353

0.07 ± 0.43

0.2

VEGF

129.67 ± 67.726

516.51 ± 649.63

0.05

MMP-9

488.60 ± 405.16

1166.64 ± 745.91

0.04

  1. Units: Cytochrome-c, ng/ml; Caspase-3, pmol AMC/min/mg; VEGF, pg/ml; MMP-9, ng/ml.
  2. *Numbers in parentheses indicate percentages.
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BMC Clinical Pathology

ISSN: 1472-6890

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