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Table 4 Cytokine production in response to stimulation in FM patients compared to healthy controls

From: Unique immunologic patterns in fibromyalgia

Cytokine

PHA

Controls

Patients

Cmean/ Pmean

P-value

N

Mean

SD

Min.

Max.

Med.

N

Mean

SD

Min.

Max.

Med.

MCP-1

90

3497

4384

69

>OOR

1823

109

1968

1993

86

>OOR

1310

1.8

0.003

IL-5

32

47.7

150.1

<OOR

853

14.1

48

7

17

<OOR

89

1.5

7

0.136

IL-6

91

2799

4182

1.2

15592

273

110

276

437

3.1

2255

108

10.2

<.001

IL-8

89

17456

24246

161

>OOR

4933

110

5751

6123

135

37981

3144

3

<.001

IL-10

65

80

94

<OOR

352

38

103

12

15

<OOR

84

6.8

6.5

<.001

IFNγ

70

1516

2425

<OOR

16902

670

101

569

1920

<OOR

15318

124

2.7

0.007

MIP-1α

91

1084

1773

1.9

9159

240

110

204

272

5.7

1598

109

5.3

<.001

MIP-1β

83

4413

5228

122

>OOR

2282

109

2900

2417

395

>OOR

2259

1.5

0.016

Cytokine

PMA/Ionomycin

Controls

Patients

C mean / P mean

P- value

N

Mean

SD

Min.

Max.

Med.

N

Mean

SD

Min.

Max.

Med.

MCP-1

91

1224

1126

150

8295

874

108

436

421

<OOR

2363

292

2.8

<.001

IL-5

87

63.8

63.9

<OOR

374.5

42.5

98

36

54

<OOR

441

17

1.8

0.002

IL-6

91

532

474

26

2108

350

108

242

301

<OOR

1509

109

2.2

<.001

IL-8

90

17607

10103

5724

>OOR

13677

109

8756

6416

215

>OOR

7503

2

<.001

IL-10

87

63

60

<OOR

254

40

90

27

37

<OOR

230

11

2.4

<.001

IFNγ

91

36726

55772

205

339591

16130

103

14584

23047

<OOR

144516

5636

2.5

0.001

MIP-1α

90

1246

1051

105

>OOR

987

109

308

294

<OOR

1551

191

4

<.001

MIP-1β

80

6389

4915

254

>OOR

5177

106

3086

4040

9.5

>OOR

1517

2.1

<.001

  1. Concentrations of cytokines in pg/ml are shown.
  2. N, number of subjects whose cytokine values were within the detection ranges.
  3. OOR, out of range.