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Table 1 Patient clinicopathological characteristics and their correlation with MMP-2, MMP-8, and MMP-9 immunoreactivity in colorectal cancer patients assessed with chi-square test

From: Lack of MMP-9 expression is a marker for poor prognosis in Dukes’ B colorectal cancer

 

MMP-2

MMP-8

MMP-9

Clinicopathological

Patients

positive

p-value

Patients

positive

p-value

Patients

positive

p-value

variable

(n=)

(n)

%

 

(n=)

(n)

%

 

(n=)

(n)

%

 

Gender

   

0.887

   

0.496

   

0.574

Female

272

153

56.3

 

257

194

75.5

 

257

158

61.5

 

Male

309

172

55.7

 

301

235

78.1

 

301

192

63.8

 

Age

   

0.107

   

0.343

   

0.197

< 65 years

244

146

59.8

 

228

183

80.3

 

238

142

59.7

 

≥ 65 years

337

179

53.1

 

320

246

76.9

 

320

208

65.0

 

Dukes’ stage

   

0.317

   

0.148

   

0.100

A

87

44

50.6

 

82

63

76.8

 

83

57

68.7

 

B

208

110

52.9

 

197

163

82.7

 

206

138

67.0

 

C

155

93

60.0

 

137

99

72.3

 

138

77

55.8

 

D

131

78

59.5

 

132

104

78.8

 

131

78

59.5

 

Dukes’ stage

   

0.066

   

0.116

   

0.016*

A and B

295

154

52.2

 

279

226

81.0

 

289

195

67.5

 

C and D

286

171

59.8

 

269

203

75.5

 

269

155

57.6

 

Differentiation (WHO grade)

   

0.116

   

0.326

   

<0.001*

1

19

9

47.4

 

19

14

73.7

 

18

12

66.7

 

2

382

211

55.2

 

368

290

78.8

 

374

254

67.9

 

3

155

86

55.5

 

138

111

80.4

 

142

77

54.2

 

4

24

19

79.2

 

22

14

63.6

 

23

7

30.4

 

missing

1

   

1

   

1

   

Histologic type

   

0.680

   

0.085

   

0.053

Adenocarcinoma

512

288

56.3

 

481

382

79.4

 

489

314

64.2

 

Mucinous carcinoma

69

37

53.6

 

67

47

70.1

 

69

36

52.2

 

Tumour location

   

0.202

   

0.073

   

0.419

Colon

315

169

53.7

 

305

247

81.0

 

311

191

61.4

 

Rectum

263

155

58.9

 

240

179

74.6

 

244

158

64.8

 

missing

3

   

3

   

3

   
  1. * = p-value significant.