From: Lack of MMP-9 expression is a marker for poor prognosis in Dukes’ B colorectal cancer
MMP-2 | MMP-8 | MMP-9 | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Clinicopathological | Patients | positive | p-value | Patients | positive | p-value | Patients | positive | p-value | |||
variable | (n=) | (n) | % | (n=) | (n) | % | (n=) | (n) | % | |||
Gender | 0.887 | 0.496 | 0.574 | |||||||||
Female | 272 | 153 | 56.3 | 257 | 194 | 75.5 | 257 | 158 | 61.5 | |||
Male | 309 | 172 | 55.7 | 301 | 235 | 78.1 | 301 | 192 | 63.8 | |||
Age | 0.107 | 0.343 | 0.197 | |||||||||
< 65 years | 244 | 146 | 59.8 | 228 | 183 | 80.3 | 238 | 142 | 59.7 | |||
≥ 65 years | 337 | 179 | 53.1 | 320 | 246 | 76.9 | 320 | 208 | 65.0 | |||
Dukes’ stage | 0.317 | 0.148 | 0.100 | |||||||||
A | 87 | 44 | 50.6 | 82 | 63 | 76.8 | 83 | 57 | 68.7 | |||
B | 208 | 110 | 52.9 | 197 | 163 | 82.7 | 206 | 138 | 67.0 | |||
C | 155 | 93 | 60.0 | 137 | 99 | 72.3 | 138 | 77 | 55.8 | |||
D | 131 | 78 | 59.5 | 132 | 104 | 78.8 | 131 | 78 | 59.5 | |||
Dukes’ stage | 0.066 | 0.116 | 0.016* | |||||||||
A and B | 295 | 154 | 52.2 | 279 | 226 | 81.0 | 289 | 195 | 67.5 | |||
C and D | 286 | 171 | 59.8 | 269 | 203 | 75.5 | 269 | 155 | 57.6 | |||
Differentiation (WHO grade) | 0.116 | 0.326 | <0.001* | |||||||||
1 | 19 | 9 | 47.4 | 19 | 14 | 73.7 | 18 | 12 | 66.7 | |||
2 | 382 | 211 | 55.2 | 368 | 290 | 78.8 | 374 | 254 | 67.9 | |||
3 | 155 | 86 | 55.5 | 138 | 111 | 80.4 | 142 | 77 | 54.2 | |||
4 | 24 | 19 | 79.2 | 22 | 14 | 63.6 | 23 | 7 | 30.4 | |||
missing | 1 | 1 | 1 | |||||||||
Histologic type | 0.680 | 0.085 | 0.053 | |||||||||
Adenocarcinoma | 512 | 288 | 56.3 | 481 | 382 | 79.4 | 489 | 314 | 64.2 | |||
Mucinous carcinoma | 69 | 37 | 53.6 | 67 | 47 | 70.1 | 69 | 36 | 52.2 | |||
Tumour location | 0.202 | 0.073 | 0.419 | |||||||||
Colon | 315 | 169 | 53.7 | 305 | 247 | 81.0 | 311 | 191 | 61.4 | |||
Rectum | 263 | 155 | 58.9 | 240 | 179 | 74.6 | 244 | 158 | 64.8 | |||
missing | 3 | 3 | 3 |