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Table 2 Univariate and multivariate analyses of OS, DFS and PFS in relation to clinical parameters and Trop-2 protein expression

From: Trop-2 protein overexpression is an independent marker for predicting disease recurrence in endometrioid endometrial carcinoma

  OS DFS PFS
Variables N=97 HR 95%CI p N=93 HR 95%CI p N=97 HR 95%CI p
Univariate analysis
Age             
<65 vs ≥65 103 1.23 0.46-3.28 0.68 93 1.06 0.41-2.75 0.90 102 1.37 0.49-3.79 0.54
FIGO stage             
III-IV vs I-II 97 17.05 5.47-53.17 <0.01 93 5.88 2.25-15.34 <0.01 96 16.73 5.28-53.03 <0.01
Tumor grade             
G1 vs G2-G3 103 0.001 -* 0.68 99 0.155 0.02-1.18 0.07 102 0.001 -* 0.69
Lymph node involvement             
positive vs negative 87 10.17 3.22-32.11 <0.01 85 6.05 2.09-17.51 <0.01 86 14.07 4.08-48.49 <0.01
Trop-2 IHC             
score=3 vs score 0/1/2 103 2.60 0.94-7.19 0.06 99 3.36 1.26-8.92 0.01 102 2.80 0.99-7.87 0.05
Multivariate analysis
Trop-2 IHC 97     93     97    
score=3 vs score 0/1/2   1.83 0.65-5.18 0.25   2.82 1.05-7.58 0.04   1.76 0.63-4.88 0.28
FIGO stage 97     93     97    
III-IV vs I-II   15.94 5.08-50.04 <0.001   5.36 2.04-14.08 <0.001   16.73 5.31-52.73 <0.001
  1. *Because of the small number of events (deaths and progressions) in the G1 EEC category, the confidence interval was not reliable.
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