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Table 2 Univariate and multivariate analyses of OS, DFS and PFS in relation to clinical parameters and Trop-2 protein expression

From: Trop-2 protein overexpression is an independent marker for predicting disease recurrence in endometrioid endometrial carcinoma

 

OS

DFS

PFS

Variables

N=97

HR

95%CI

p

N=93

HR

95%CI

p

N=97

HR

95%CI

p

Univariate analysis

Age

            

<65 vs ≥65

103

1.23

0.46-3.28

0.68

93

1.06

0.41-2.75

0.90

102

1.37

0.49-3.79

0.54

FIGO stage

            

III-IV vs I-II

97

17.05

5.47-53.17

<0.01

93

5.88

2.25-15.34

<0.01

96

16.73

5.28-53.03

<0.01

Tumor grade

            

G1 vs G2-G3

103

0.001

-*

0.68

99

0.155

0.02-1.18

0.07

102

0.001

-*

0.69

Lymph node involvement

            

positive vs negative

87

10.17

3.22-32.11

<0.01

85

6.05

2.09-17.51

<0.01

86

14.07

4.08-48.49

<0.01

Trop-2 IHC

            

score=3 vs score 0/1/2

103

2.60

0.94-7.19

0.06

99

3.36

1.26-8.92

0.01

102

2.80

0.99-7.87

0.05

Multivariate analysis

Trop-2 IHC

97

   

93

   

97

   

score=3 vs score 0/1/2

 

1.83

0.65-5.18

0.25

 

2.82

1.05-7.58

0.04

 

1.76

0.63-4.88

0.28

FIGO stage

97

   

93

   

97

   

III-IV vs I-II

 

15.94

5.08-50.04

<0.001

 

5.36

2.04-14.08

<0.001

 

16.73

5.31-52.73

<0.001

  1. *Because of the small number of events (deaths and progressions) in the G1 EEC category, the confidence interval was not reliable.
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BMC Clinical Pathology

ISSN: 1472-6890

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