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Table 1 Clinical and pathologic characteristics of 118 endometrioid endometrial cancer patients and their association to Trop-2 protein expression

From: Trop-2 protein overexpression is an independent marker for predicting disease recurrence in endometrioid endometrial carcinoma

 

    Trop-2 protein expression

  

Variable

n

Score≤1 n (%)

Score=2 n (%)

Score=3 n(%)

p value*

Age at diagnosis

     

 <65

51

22 (43.1)

17 (33.3)

12 (23.5)

 
     

0.89

 ≥65

67

28 (41.8)

26 (38.8)

13 (19.4)

 

FIGO stage(2009 criteria)

     

 I-II

86

37 (43)

33 (38.4)

16 (18.6)

 
     

0.56

 III-IV

22

8 (36.4)

6 (27.3)

8 (36.4)

 

 Unknown

10

5 (50)

4 (40)

1 (10)

 

WHO grading

     

 Grade 1

34

21 (61.8)

11 (32.4)

2 (5.9)

 
     

0.024

 Grade 2-3

84

29 (34.5)

32 (38.1)

23 (27.4)

 

Myometrial invasion

     

 M0+M1

55

26 (47.3)

22 (40)

7 (12.7)

 
     

0.08

 M2

63

24 (38.1)

21 (33.3)

18 (28.6)

 

Lymph node status

     

 Negative

79

35 (44.3)

28 (35.4)

16 (20.3)

 
     

0.69

 Positive

15

5 (33.3)

5 (33.3)

5 (33.3)

 

 Unknown

24

10 (41.7)

10 (41.7)

4 (16.7)

 

Cervical involvement

     

 Absent

83

37 (44.6)

33 (39.8)

13 (15.7)

 

 Glandular involvement

16

10 (62.5)

4 (25)

2 (12.5)

<0.01$

 Stromal involvement

18

3 (16.7)

6 (33.3)

9 (50)

 

 Unknown

1

0 (0)

0 (0)

1 (100)

 

Adnexal involvement

     

 Negative

108

45 (41.7)

42 (38.9)

21 (19.4)

0.97

 Positive

9

5 (55.6)

0 (0)

4 (44.4)

 

 Unknown

1

0 (0)

1 (100)

0 (0)

 

Peritoneal cytology

     

 Negative

100

40 (40)

37 (37)

23 (23)

 
     

0.44

 Positive

8

4 (50)

2 (25)

2 (25)

 

 Unknown

10

6 (60)

4 (40)

0 (0)

 

Lymphovascular invasion

     

 Absent

48

22 (45.8)

20 (41.7)

6 (12.5)

 
     

0.13

 Present

56

21 (37.5)

20 (35.7)

15 (26.8)

 

 Unknown

14

7 (50)

3 (21.4)

4 (28.6)

 

Adjuvant Treatment

     

 None

57

31 (54.4)

20 (35.1)

6 (10.5)

 

 Radiotherapy

36

12 (33.3)

13 (36.1)

11 (30.6)

 

 Chemotherapy

8

3 (37.5)

1 (12.5)

4 (50.0)

0.094$

 Radiotherapy+Chemotherapy

9

2 (22.2)

5 (55.6)

2 (22.2)

 

 Unknown

8

5 (62.5)

2 (25.0)

1 (12.5)

 

Parity

     

 Nulliparity

22

10 (45.5)

7 (31.8)

5 (22.7)

 
     

0.72

 Multiparity

88

34 (38.6)

35 (39.8)

19 (21.6)

 

 Unknown

8

6 (75)

1 (12.5)

1 (12.5)

 

Body Mass Index

     

 <25

36

12 (33.3)

14 (38.9)

10 (27.8)

 
     

0.58

 ≥25

64

27 (42.2)

24 (37.5)

13 (20.3)

 

 Unknown

18

11 (61.1)

5 (27.8)

2 (11.1)

 

Hypertension

     

 Negative

48

18 (37.5)

18 (37.5)

12 (25)

 
     

0.26

 Positive

63

27 (42.9)

24 (38.1)

12 (19)

 

 Unknown

7

5 (71.4)

1 (14.3)

1 (14.3)

 

Diabetes

     

 Negative

96

38 (39.6)

39 (40.6)

19 (19.8)

 
     

0.95

 Positive

15

8 (53.3)

2 (13.3)

5 (33.3)

 

 Unknown

7

4 (57.1)

2 (28.6)

1 (14.3)

 

Menopausal Status

     

 Premenopausal

18

7 (38.9)

5 (27.8)

6 (33.3)

 
     

0.33

 Postmenopausal

94

39 (41.5)

37 (39.4)

18 (19.1)

 

 Unknown

6

4 (66.7)

1 (16.7)

1 (16.7)

 

Smoking

     

 Negative

82

29 (35.4)

35 (42.7)

18 (22)

 
     

0.91

 Positive

20

9 (45)

6 (30)

5 (25)

 

 Unknown

16

12 (75)

2 (12.5)

2 (12.5)

 
  1. * Exact Wilcoxon-Mann–Whitney test.
  2. $ Non-parametric ANOVA.
  3. Unknown values were considered as missing and therefore excluded from the statistical analysis.