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Table 4 Excerpt of a list of the probabilities to detect a 5% bias with 95% certainty at the limits of the reference ranges limited to the comparison of tubes 11 to tubes 22.

From: Effects of different centrifugation conditions on clinical chemistry and Immunology test results

 

11:22

 

11:22

Analyse

Ref. limits

Bias

95% Cl

SE

Bias Goal

p

Analyse

Ref. limits

Bias

95% Cl

SE

Bias Goal

p

Alb

35

0.3

0.0 to 0.5

0.12

1.8

<0.0001

HDL

0.9

0.0

0.0 to 0.0

0.00

0.0

<0.0001

Alb

58

1.6

-0.1 to 3.3

0.85

2.9

0.0683

Iron

10.6

0.1

0.0 to 0.2

0.05

0.5

<0.0001

AP

117

0.5

-0.3 to 1.2

0.39

5.9

<0.0001

Iron

28.3

0.4

0.1 to 0.8

0.17

1.4

<0.0001

ALTL

41

0.2

-0.1 to 0.6

0.19

2.1

<0.0001

K

3.5

0.0

0.0 to 0.1

0.01

0.2

<0.0001

Amy-P

53

0.0

-0.4 to 0.5

0.23

2.7

<0.0001

K

4.5

0.0

0.0 to 0.1

0.03

0.2

<0.0001

Amyl

100

1.0

0.3 to 1.7

0.35

5.0

<0.0001

LDH

288

10.1

0.9 to 19.3

4.56

14.4

0.1746

ASTL

37

0.2

-0.2 to 0.6

0.19

1.9

<0.0001

LDL

3.9

0.1

0.0 to 0.2

0.04

0.2

0.0019

Bili-D

2

0.0

0.0 to 0.1

0.03

0.1

0.0039

Lipe

60

0.5

0.0 to 1.1

0.28

3.0

<0.0001

Bili-T

20

0.0

-0.2 to 0.3

0.13

1.0

<0.0001

Mg

0.75

0.0

0.0 to 0.0

0.00

0.0

0.0138

Ca

2.02

0.0

0.0 to 0.0

0.01

0.1

<0.0001

Mg

1.25

0.0

0.0 to 0.0

0.01

0.1

<0.0001

Ca

2.6

0.0

0.0 to 0.0

0.01

0.1

<0.0001

Myo

28

0.2

-0.2 to 0.5

0.16

1.4

<0.0001

CHE

3000

-7.7

-61.1 to 45.7

26.47

150.0

<0.0001

Myo

72

-0.3

-0.9 to 0.3

0.31

3.6

<0.0001

CHE

11000

132.0

8.9 to 255.0

60.99

550.0

<0.0001

Na

135

0.1

-0.2 to 0.3

0.13

6.8

<0.0001

Chol

3.1

0.0

-0.1 to 0.0

0.03

0.2

<0.0001

Na

145

-0.5

-1.2 to 0.2

0.34

7.3

<0.0001

Chol

6.5

0.1

0.0 to 0.2

0.07

0.3

0.0011

Phos

0.87

0.0

0.0 to 0.0

0.01

0.0

<0.0001

CK

195

0.8

-0.9 to 2.5

0.82

9.8

<0.0001

Phos

1.45

0.0

0.0 to 0.0

0.01

0.1

<0.0001

CKMB

4.94

-0.1

-0.2 to 0.0

0.04

0.2

<0.0001

Pro-BNP

125

0.3

-0.9 to 1.6

0.63

6.3

<0.0001

CO2

22

-0.1

-0.4 to 0.1

0.11

1.1

<0.0001

PTH

1.59

0.0

-0.1 to 0.1

0.04

0.1

0.0435

CO2

29

-0.4

-0.7 to -0.0

0.17

1.5

<0.0001

PTH

9.33

-0.1

-0.3 to -0.0

0.05

0.5

<0.0001

Cort

82

0.9

-5.3 to 7.1

3.07

4.1

0.1509

RubG

10

0.0

-0.4 to 0.4

0.19

0.5

0.0111

Cort

958

0.3

-10.4 to 10.9

5.27

47.9

<0.0001

T3

1.3

0.0

0.0 to 0.0

0.01

0.1

<0.0001

Crea

59

0.1

-0.4 to 0.7

0.29

3.0

<0.0001

T3

3.1

0.0

-0.1 to 0.1

0.05

0.2

0.0054

Crea

104

0.0

-0.5 to 0.4

0.23

5.2

<0.0001

TN-T

0.01

0.0

0.0 to 0.0

0.00

0.0

<0.0001

CRP

10

0.1

-0.1 to 0.2

0.08

0.5

<0.0001

TNT-hs

0.014

0.0

0.0 to -0.0

0.00

0.0

<0.0001

Cl

97

0.1

-0.3 to 0.5

0.18

4.9

<0.0001

ToxoG

1

0.0

0.0 to 0.0

0.00

0.1

<0.0001

Cl

110

0.0

-0.4 to 0.4

0.20

5.5

<0.0001

TP

66

0.4

0.0 to 0.8

0.19

3.3

<0.0001

Ferri

30

-0.1

-0.4 to 0.2

0.15

1.5

<0.0001

TP

87

0.8

-0.4 to 2.0

0.59

4.4

<0.0001

Ferri

400

2.7

-0.9 to 6.2

1.77

20.0

<0.0001

Trigl

2.3

0.0

0.0 to 0.0

0.01

0.1

<0.0001

Fol

10.4

-0.1

-0.6 to 0.4

0.24

0.5

0.0484

Trfe

23

0.1

-0.1 to 0.3

0.09

1.2

<0.0001

Fol

78.9

1.6

-0.9 to 4.1

1.25

3.9

0.0343

Trfe

45

1.0

-0.2 to 2.3

0.62

2.3

0.0273

FT3

3.1

0.0

0.0 to 0.1

0.02

0.2

<0.0001

TSH

0.34

0.0

0.0 to 0.0

0.01

0.0

0.0873

FT3

6.8

-0.1

-0.2 to 0.1

0.07

0.3

0.0003

TSH

5.6

0.0

-0.1 to 0.1

0.05

0.3

<0.0001

FT4

12

0.0

-0.1 to 0.1

0.06

0.6

<0.0001

UA

420

0.9

-0.4 to 2.2

0.63

21.0

<0.0001

FT4

22

0.2

-0.1 to 0.4

0.11

1.1

<0.0001

Ureal

3

0.0

0.0 to 0.0

0.01

0.2

<0.0001

GGT

49

0.2

-0.1 to 0.6

0.18

2.5

<0.0001

Ureal

8

0.0

0.0 to 0.0

0.01

0.4

<0.0001

Gluc

3.9

0.0

-0.1 to 0.1

0.06

0.2

0.0029

VitB12

133

1.8

-2.5 to 6.1

2.15

6.7

0.0144

Gluc

5.8

0.0

0.0 to 0.1

0.04

0.3

<0.0001

VitB12

675

0.8

-7.7 to 9.3

4.20

33.8

<0.0001

HAV

20

0.0

-0.1 to 0.1

0.04

1.0

<0.0001

VitD

75

0.6

-1.0 to 2.3

0.80

3.8

0.0002

HCGbeta

2

0.0

0.0 to 0.1

0.02

0.1

0.0002

       
  1. Those conditions not sensitive enough to detect a 5% bias were retested for a 10, 20, 30 or 40% bias (data not shown). The column heading Ref. limits means limits of reference ranges. At these concentrations of the analyte, the probability was tested to detect a 5% bias. Bias: The calculated deviation of the Deming regression line and its 95% confidence intervals (CI) and the standard error are given. Bias goal corresponds to a 5% deviation of the Deming regression line from identity at the tested analyte concentration. The full information on all comparisons is given in supplemental Table S2.