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Table 4 Excerpt of a list of the probabilities to detect a 5% bias with 95% certainty at the limits of the reference ranges limited to the comparison of tubes 11 to tubes 22.

From: Effects of different centrifugation conditions on clinical chemistry and Immunology test results

  11:22   11:22
Analyse Ref. limits Bias 95% Cl SE Bias Goal p Analyse Ref. limits Bias 95% Cl SE Bias Goal p
Alb 35 0.3 0.0 to 0.5 0.12 1.8 <0.0001 HDL 0.9 0.0 0.0 to 0.0 0.00 0.0 <0.0001
Alb 58 1.6 -0.1 to 3.3 0.85 2.9 0.0683 Iron 10.6 0.1 0.0 to 0.2 0.05 0.5 <0.0001
AP 117 0.5 -0.3 to 1.2 0.39 5.9 <0.0001 Iron 28.3 0.4 0.1 to 0.8 0.17 1.4 <0.0001
ALTL 41 0.2 -0.1 to 0.6 0.19 2.1 <0.0001 K 3.5 0.0 0.0 to 0.1 0.01 0.2 <0.0001
Amy-P 53 0.0 -0.4 to 0.5 0.23 2.7 <0.0001 K 4.5 0.0 0.0 to 0.1 0.03 0.2 <0.0001
Amyl 100 1.0 0.3 to 1.7 0.35 5.0 <0.0001 LDH 288 10.1 0.9 to 19.3 4.56 14.4 0.1746
ASTL 37 0.2 -0.2 to 0.6 0.19 1.9 <0.0001 LDL 3.9 0.1 0.0 to 0.2 0.04 0.2 0.0019
Bili-D 2 0.0 0.0 to 0.1 0.03 0.1 0.0039 Lipe 60 0.5 0.0 to 1.1 0.28 3.0 <0.0001
Bili-T 20 0.0 -0.2 to 0.3 0.13 1.0 <0.0001 Mg 0.75 0.0 0.0 to 0.0 0.00 0.0 0.0138
Ca 2.02 0.0 0.0 to 0.0 0.01 0.1 <0.0001 Mg 1.25 0.0 0.0 to 0.0 0.01 0.1 <0.0001
Ca 2.6 0.0 0.0 to 0.0 0.01 0.1 <0.0001 Myo 28 0.2 -0.2 to 0.5 0.16 1.4 <0.0001
CHE 3000 -7.7 -61.1 to 45.7 26.47 150.0 <0.0001 Myo 72 -0.3 -0.9 to 0.3 0.31 3.6 <0.0001
CHE 11000 132.0 8.9 to 255.0 60.99 550.0 <0.0001 Na 135 0.1 -0.2 to 0.3 0.13 6.8 <0.0001
Chol 3.1 0.0 -0.1 to 0.0 0.03 0.2 <0.0001 Na 145 -0.5 -1.2 to 0.2 0.34 7.3 <0.0001
Chol 6.5 0.1 0.0 to 0.2 0.07 0.3 0.0011 Phos 0.87 0.0 0.0 to 0.0 0.01 0.0 <0.0001
CK 195 0.8 -0.9 to 2.5 0.82 9.8 <0.0001 Phos 1.45 0.0 0.0 to 0.0 0.01 0.1 <0.0001
CKMB 4.94 -0.1 -0.2 to 0.0 0.04 0.2 <0.0001 Pro-BNP 125 0.3 -0.9 to 1.6 0.63 6.3 <0.0001
CO2 22 -0.1 -0.4 to 0.1 0.11 1.1 <0.0001 PTH 1.59 0.0 -0.1 to 0.1 0.04 0.1 0.0435
CO2 29 -0.4 -0.7 to -0.0 0.17 1.5 <0.0001 PTH 9.33 -0.1 -0.3 to -0.0 0.05 0.5 <0.0001
Cort 82 0.9 -5.3 to 7.1 3.07 4.1 0.1509 RubG 10 0.0 -0.4 to 0.4 0.19 0.5 0.0111
Cort 958 0.3 -10.4 to 10.9 5.27 47.9 <0.0001 T3 1.3 0.0 0.0 to 0.0 0.01 0.1 <0.0001
Crea 59 0.1 -0.4 to 0.7 0.29 3.0 <0.0001 T3 3.1 0.0 -0.1 to 0.1 0.05 0.2 0.0054
Crea 104 0.0 -0.5 to 0.4 0.23 5.2 <0.0001 TN-T 0.01 0.0 0.0 to 0.0 0.00 0.0 <0.0001
CRP 10 0.1 -0.1 to 0.2 0.08 0.5 <0.0001 TNT-hs 0.014 0.0 0.0 to -0.0 0.00 0.0 <0.0001
Cl 97 0.1 -0.3 to 0.5 0.18 4.9 <0.0001 ToxoG 1 0.0 0.0 to 0.0 0.00 0.1 <0.0001
Cl 110 0.0 -0.4 to 0.4 0.20 5.5 <0.0001 TP 66 0.4 0.0 to 0.8 0.19 3.3 <0.0001
Ferri 30 -0.1 -0.4 to 0.2 0.15 1.5 <0.0001 TP 87 0.8 -0.4 to 2.0 0.59 4.4 <0.0001
Ferri 400 2.7 -0.9 to 6.2 1.77 20.0 <0.0001 Trigl 2.3 0.0 0.0 to 0.0 0.01 0.1 <0.0001
Fol 10.4 -0.1 -0.6 to 0.4 0.24 0.5 0.0484 Trfe 23 0.1 -0.1 to 0.3 0.09 1.2 <0.0001
Fol 78.9 1.6 -0.9 to 4.1 1.25 3.9 0.0343 Trfe 45 1.0 -0.2 to 2.3 0.62 2.3 0.0273
FT3 3.1 0.0 0.0 to 0.1 0.02 0.2 <0.0001 TSH 0.34 0.0 0.0 to 0.0 0.01 0.0 0.0873
FT3 6.8 -0.1 -0.2 to 0.1 0.07 0.3 0.0003 TSH 5.6 0.0 -0.1 to 0.1 0.05 0.3 <0.0001
FT4 12 0.0 -0.1 to 0.1 0.06 0.6 <0.0001 UA 420 0.9 -0.4 to 2.2 0.63 21.0 <0.0001
FT4 22 0.2 -0.1 to 0.4 0.11 1.1 <0.0001 Ureal 3 0.0 0.0 to 0.0 0.01 0.2 <0.0001
GGT 49 0.2 -0.1 to 0.6 0.18 2.5 <0.0001 Ureal 8 0.0 0.0 to 0.0 0.01 0.4 <0.0001
Gluc 3.9 0.0 -0.1 to 0.1 0.06 0.2 0.0029 VitB12 133 1.8 -2.5 to 6.1 2.15 6.7 0.0144
Gluc 5.8 0.0 0.0 to 0.1 0.04 0.3 <0.0001 VitB12 675 0.8 -7.7 to 9.3 4.20 33.8 <0.0001
HAV 20 0.0 -0.1 to 0.1 0.04 1.0 <0.0001 VitD 75 0.6 -1.0 to 2.3 0.80 3.8 0.0002
HCGbeta 2 0.0 0.0 to 0.1 0.02 0.1 0.0002        
  1. Those conditions not sensitive enough to detect a 5% bias were retested for a 10, 20, 30 or 40% bias (data not shown). The column heading Ref. limits means limits of reference ranges. At these concentrations of the analyte, the probability was tested to detect a 5% bias. Bias: The calculated deviation of the Deming regression line and its 95% confidence intervals (CI) and the standard error are given. Bias goal corresponds to a 5% deviation of the Deming regression line from identity at the tested analyte concentration. The full information on all comparisons is given in supplemental Table S2.