Table 3 Cox uni- and multivariate distant disease-free survival analyses

Ki-67 (Automated assessment of extent of staining)

   Low

1.00

   Moderate

1.77

1.31-2.37

< 0.0001

   High

2.34

1.76-3.10

< 0.0001

Ki-67 (Visually assessed proliferation index)

   Negative

1.00

   Moderate

1.41

0.83-2.39

0.207

   High

2.58

1.52-4.37

< 0.0001

Covariate (multivariate analyses)

HR

95% CI

P

Ki-67 (Automated assessment of extent of staining)

   Low

1.00

   Moderate

1.62

1.10-2.39

0.014

   High

1.73

1.19-2.51

0.004

Tumour size*

1.23

1.14-1.34

< 0.0001

No. of positive axillary lymph nodes†

1.14

1.11-1.18

< 0.0001

Histological grade (grade 3 or 2 vs. 1)

2.17

1.36-3.47

0.001

Detection at mammography screening

0.50

0.32-0.78

0.002

Age at diagnosis

   < 50

1.00

   >50

1.18

0.90-1.55

0.221

Ki-67 (Visually assessed proliferation index)

   Negative

1.00

   Moderate

0.71

0.37-1.38

0.311

   High

1.03

0.53-2.01

0.920

Tumour size*

1.25

1.15-1.35

< 0.0001

No. of positive axillary lymph nodes†

1.14

1.11-1.18

< 0.0001

Histological grade (grade 3 or 2 vs. 1)

2.36

1.46-3.80

< 0.0001

Detection at mammography screening

0.47

0.30-0.74

0.001

Age at diagnosis

   < 50

1.00

   >50

1.20

0.92-1.58

0.185