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Table 2 Association of automated assessment of Ki-67 extent of staining with clinicopathological characteristics

From: Development and evaluation of a virtual microscopy application for automated assessment of Ki-67 expression in breast cancer

Characteristic

Automated assessment of Ki-67 extent of staining

P

 

Low N (%)

Moderate N (%)

High N (%)

 

All tissue samples (N = 1334) *

406 (30)

446 (33)

482 (36)

 

Ki-67 expression (visual)

    

   High

13 (3)

102 (22)

359 (76)

< 0.0001

   Moderate

293 (41)

314 (44)

112 (16)

 

   Negative

82 (83)

15 (15)

2 (2)

 

   Not available

18 (43)

15 (36)

9 (21)

 

Age at diagnosis (y)

    

   < 35

2 (6)

13 (36)

21 (58)

0.0008

   35-50

101 (28)

120 (33)

141 (39)

 

   50-65

160 (36)

133 (30)

149 (34)

 

   >65

143 (29)

180 (36)

171 (35)

 

Method of detection

    

   Mammography screening

102 (41)

81 (33)

66 (27)

0.0001

   Other

298 (28)

355 (34)

403 (38)

 

   Not available

6 (21)

10 (34)

13 (45)

 

Primary tumour diameter (cm)

    

   < 0.5

8 (44)

8 (44)

2 (11)

< 0.0001

   0.5-1

82 (42)

66 (34)

49 (25)

 

   1-2

182 (34)

180 (34)

172 (32)

 

   2-5

104 (22)

156 (33)

212 (45)

 

   > 5

13 (24)

14 (25)

28 (51)

 

   Not available

17 (29)

22 (38)

19 (33)

 

No. of positive axillary nodes

    

   0

276 (35)

253 (32)

264 (33)

0.0142

   1-3

80 (27)

98 (33)

119 (40)

 

   4-9

26 (23)

45 (40)

41 (37)

 

   ≥ 10

5 (16)

11 (35)

15 (48)

 

   Not available

19 (19)

39 (39)

43 (43

 

Histological grade

    

   1

118 (52)

73 (32)

37 (16)

< 0.0001

   2

122 (26)

184 (39)

171 (36)

 

   3

34 (12)

67 (23)

188 (65)

 

   Not available

132 (39)

122 (36)

86 (25)

 

Histological type

    

   Ductal

275 (27)

342 (34)

402 (40)

< 0.0001

   Lobular

87 (46)

67 (35)

36 (19)

 

   Special

44 (35)

37 (30)

44 (35)

 

ER expression

    

   Positive

301 (35)

324 (38)

234 (27)

< 0.0001

   Negative

69 (17)

102 (26)

228 (57)

 

   Not available

36 (47)

20 (26)

20 (26)

 

PR expression

    

   Positive

254 (37)

270 (39)

171 (25)

< 0.0001

   Negative

122 (21)

151 (27)

295 (52)

 

   Not available

30 (42)

25 (35)

16 (23)

 

HER2 amplification

    

   Positive

34 (14)

75 (31)

134 (55)

< 0.0001

   Negative

331 (33)

333 (34)

327 (33)

 

   Not available

41 (41)

38 (38)

21 (21)

 

HER2 expression

    

   Positive

26 (13)

60 (29)

121 (58)

< 0.0001

   Negative

333 (33)

340 (34)

324 (33)

 

   Not available

47 (36)

46 (35)

37 (28)

 

p53 expression

    

   High

16 (7)

50 (22)

158 (71)

< 0.0001

   Moderate

98 (27)

135 (37)

129 (36)

 

   Low

222 (39)

196 (34)

155 (27)

 

   Not available

70 (40)

65 (37)

40 (23)

 

Molecular subtype

    

   Basal

11 (12)

15 (16)

69 (73)

< 0.0001

   HER2+/HR-

14 (12)

33 (28)

70 (60)

 

   Luminal A

291 (38)

288 (37)

191 (25)

 

   Luminal B

19 (16)

37 (32)

60 (52)

 

   Five-marker negative

8 (19)

6 (14)

28 (67)

 

   Unclassified

9 (16)

18 (32)

29 (52)

 

   Not available

54 (39)

49 (36)

35 (25)

 
  1. * due to ties the number of samples in each tertile is not equal