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Figure 2 | BMC Clinical Pathology

Figure 2

From: Molecular preservation by extraction and fixation, mPREF: a method for small molecule biomarker analysis and histology on exactly the same tissue

Figure 2

Composite panel showing H&E and PIN4 IHC of biopsies processed with mPREF. Histology of prostate biopsies processed using the mPREF method. The figure compares histopathology of benign glands (top row) to malignant glands (middle row) stained with H&E. 4 micron sections were prepared. Each frame is from a separate subject. The bottom row shows IHC staining for PIN-4 cocktail wherein brown basal staining is present in benign prostatic glands and absent in tumor glands. In reciprocal fashion, racemase staining, indicated by red pigment, is present in malignant glands and absent from normal glands. Each frame is from a different subject.

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BMC Clinical Pathology

ISSN: 1472-6890

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