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Table 3 COLD-PCR Enhancement According to Specific KRAS Mutation

From: COLD-PCR enhanced melting curve analysis improves diagnostic accuracy for KRAS mutations in colorectal carcinoma

Mutation

Base Change

Frequency in Colorectal Cancer

Predicted To Enhance With Fast COLD-PCR?

Fold-Enhancement With COLD-PCR

G12D

GG T to GA T

35%

Yes

11.5

G12V

GG T to GT T

22%

Yes

11.5

G13D

GG C to GA C

19%

Yes

9.8

G12C

G GT to T GT

9%

Yes

14.0

G12S

G GT to A GT

7%

Yes

ND

G12A

GG T to GC T

7%

No

ND

G12R

G GT to C GT

1%

No

1.1

G13R

G GC to C GC

< 1%

No

2.5

Other

Multiple

< 1%

Yes/No

ND

  1. ND = no data; Frequency Is Based on KRAS Mutations Colorectal Cancer Reported in the COSMIC Database accessed July 2010 http://www.sanger.ac.uk/perl/genetics/CGP.