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Table 2 Mutations associated with RIF and INH resistance in the eight resistant isolates.

From: Use of the GenoType® MTBDRplus assay to assess drug resistance of Mycobacterium tuberculosis isolates from patients in rural Uganda

 

RIF susceptibility pattern

INH susceptibility pattern

     

KatG probes

inhA probes

 

Study

number

Indirect

Method

rpoβ gene

WT probes

rpoβ gene

Mutant probes

Indirect

Method

WT

Mutant

WT1

WT2

Mutant

08

R

 

D516V, H526Y,

H526D

R

WT

 

wt

WT

C15T

29

R

 

D516V

S

WT

 

WT

WT

 

47

R

 

D516V

S

WT

 

WT

WT

 

102

R

  

R

wt

S315T1

WT

WT

 

291

R

Δ8

S531L

R

wt

S315T1

WT

WT

 

246

S

  

R

wt

S315T2

WT

WT

 

248

R

Δ1

 

S

WT

 

WT

WT

 

437

R

 

S531L

S

WT

 

WT

WT

 
  1. INH = isoniazid; RIF = rifampicin; R = drug resistant isolate; S = drug susceptible isolate; Indirect method = proportion method on Lowenstein-Jensen media.