Histopathology

Section edited by Rui Henrique

This section considers articles on all aspect of histopathology and includes articles investigating microscopic examinations of tissues from biopsies or surgical specimens, we encourage submission of studies on biomarkers.

  1. Research article

    High expression of EphA3 (erythropoietin-producing hepatocellular A3) in gastric cancer is associated with metastasis and poor survival

    As the major subfamily of receptor tyrosine, erythropoietin-producing hepatocellular (Eph) receptor has been related to progression and prognosis in different types of tumors. However, the role and mechanism o...

    Baongoc Nasri, Mikito Inokuchi, Toshiaki Ishikawa, Hiroyuki Uetake, Yoko Takagi, Sho Otsuki, Kazuyuki Kojima and Tatsuyuki Kawano

    BMC Clinical Pathology 2017 17:8

    Published on: 27 April 2017

  2. Case report

    Bone pathologic fracture revealing an unusual association: coexistence of Langerhans cell histiocytosis with Rosai-Dorfman disease

    The coexistence of Rosai-Dorfman disease (RDD) with Langerhans cell histiocytosis (LCH) is very rare, as to date only 17 cases have been reported in the english literature. The pathophysiology of this uncommon...

    Boubacar Efared, Asmae Mazti, Badarou Chaibou, Gabrielle Atsame-Ebang, Ibrahim Sory Sidibé, Layla Tahiri, Fatimazahra Erregad, Nawal Hammas, Abdelmajid El Mrini, Hinde El Fatemi and Laila Chbani

    BMC Clinical Pathology 2017 17:5

    Published on: 7 April 2017

  3. Research article

    Expression of human epidermal growth factor receptor 2 in bladder urothelial carcinoma

    Urothelial bladder carcinoma (UBC) is one of the most prevalent cancers in men worldwide. Human epidermal growth factor receptor 2 (HER2) expression has been detected in a wide range of urothelial carcinoma. D...

    Mohamed Reda El Ochi, Mohamed Oukabli, Elarbi Bouaiti, Hafsa Chahdi, Adil Boudhas, Mohamed Allaoui, Ahmed Ameur, Mohamed Abbar and Abderrahmane Al Bouzidi

    BMC Clinical Pathology 2017 17:3

    Published on: 4 April 2017

  4. Research article

    Peritumoral lymphatic vessel density and invasion detected with immunohistochemical marker D240 is strongly associated with distant metastasis in breast carcinoma

    Detection of vascular invasion by hematoxylin and eosin staining is the current pathological assessment practice to diagnose breast carcinoma. However, conventional hematoxylin and eosin staining failed to dis...

    Nur Fatiha Norhisham, Choi Yen Chong and Sabreena Safuan

    BMC Clinical Pathology 2017 17:2

    Published on: 10 February 2017

  5. Case report

    Mycetoma in a non-endemic area: a diagnostic challenge

    Mycetoma is a chronic granulomatous infectious disease caused by filamentous bacteria or by fungi. The disease is endemic in certain tropical and subtropical areas of the world but can be found elsewhere posin...

    Boubacar Efared, Layla Tahiri, Marou Soumana Boubacar, Gabrielle Atsam-Ebang, Nawal Hammas, El Fatemi Hinde and Laila Chbani

    BMC Clinical Pathology 2017 17:1

    Published on: 2 February 2017

  6. Research article

    Expression of podocalyxin-like protein is an independent prognostic biomarker in resected esophageal and gastric adenocarcinoma

    Podocalyxin-like protein (PODXL) is a cell surface transmembrane glycoprotein, the expression of which has been associated with poor prognosis in a range of malignancies. The aim of this study was to investiga...

    David Borg, Charlotta Hedner, Björn Nodin, Anna Larsson, Anders Johnsson, Jakob Eberhard and Karin Jirström

    BMC Clinical Pathology 2016 16:13

    Published on: 29 July 2016

  7. Research article

    The study of calcified atherosclerotic arteries: an alternative to evaluate the composition of a problematic tissue reveals new insight including metakaryotic cells

    Calcifications of atherosclerotic plaques represent a controversial issue as they either lead to the stabilization or rupture of the lesion. However, the cellular key players involved in the progression of the...

    Silvia Fittipaldi, Francesco Vasuri, Alessio Degiovanni, Rodolfo Pini, Mauro Gargiulo, Andrea Stella, Gianandrea Pasquinelli, William G. Thilly and Elena V. Gostjeva

    BMC Clinical Pathology 2016 16:12

    Published on: 29 July 2016

  8. Research article

    Histopathological techniques for the diagnosis of combat-related invasive fungal wound infections

    Effective management of trauma-related invasive fungal wound infections (IFIs) depends on early diagnosis and timely initiation of treatment. We evaluated the utility of routine staining, histochemical stains ...

    Sarah M. Heaton, Amy C. Weintrob, Kevin Downing, Bryan Keenan, Deepak Aggarwal, Faraz Shaikh, David R. Tribble and Justin Wells

    BMC Clinical Pathology 2016 16:11

    Published on: 7 July 2016

  9. Case report

    Liver cancer with concomitant TP53 and CTNNB1 mutations: a case report

    In the spectrum of molecular alterations found in hepatocellular carcinoma (HCC), somatic mutations in the WNT/β-catenin pathway and the p53/cell cycle control pathway are among the most frequent ones. It has ...

    Juliane Friemel, Markus Rechsteiner, Marion Bawohl, Lukas Frick, Beat Müllhaupt, Mickaël Lesurtel and Achim Weber

    BMC Clinical Pathology 2016 16:7

    Published on: 1 June 2016

  10. Case report

    Bone metastasis from malignant phyllodes breast tumor: report of two cases

    Phyllodes tumors are rare fibroepithelial tumors accounting for less than 1 % of all breast neoplasms. They are malignant in 20 % of cases. Only a few cases of malignant phyllodes tumors metastatic to bone hav...

    Mohamed Reda El Ochi, Mehdi Toreis, Mohamed Benchekroun, Zineb Benkerroum, Mohamed Allaoui, Mohamed Ichou, Basma El Khannoussi, Abderrahman Albouzidi and Mohamed Oukabli

    BMC Clinical Pathology 2016 16:4

    Published on: 29 February 2016

  11. Research article

    Histopathological characterization of corrosion product associated adverse local tissue reaction in hip implants: a study of 285 cases

    Adverse local tissue reaction (ALTR), characterized by a heterogeneous cellular inflammatory infiltrate and the presence of corrosion products in the periprosthetic soft tissues, has been recognized as a mecha...

    Benjamin F. Ricciardi, Allina A. Nocon, Seth A. Jerabek, Gabrielle Wilner, Elianna Kaplowitz, Steven R. Goldring, P. Edward Purdue and Giorgio Perino

    BMC Clinical Pathology 2016 16:3

    Published on: 27 February 2016

  12. Case report

    Primary leiomyosarcoma of the submandibular gland: a case report

    Leiomyosarcoma is a rare malignant mesenchymal tumor that represents 5–7 % of all soft tissue sarcomas. The occurrence of this tumor in the salivary glands is exceptional. Only five cases are reported in the s...

    Mohamed Reda El Ochi, Hafsa Chahdi, Issam Rharrassi, Abderrahman Albouzidi and Mohamed Oukabli

    BMC Clinical Pathology 2015 15:22

    Published on: 15 December 2015

  13. Research article

    Prognostic and predictive significance of podocalyxin-like protein expression in pancreatic and periampullary adenocarcinoma

    Adenocarcinoma of the periampullary region is associated with poor prognosis and new prognostic and treatment predictive biomarkers are needed for improved treatment. Membranous expression of podocalyxin-like ...

    Margareta Heby, Jakob Elebro, Björn Nodin, Karin Jirström and Jakob Eberhard

    BMC Clinical Pathology 2015 15:10

    Published on: 30 May 2015

  14. Research article

    Tumor-specific expression of HMG-CoA reductase in a population-based cohort of breast cancer patients

    The mevalonate pathway synthetizes cholesterol, steroid hormones, and non-steriod isoprenoids necessary for cell survival. 3-Hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) is the rate-limiting enzyme of...

    Emma Gustbée, Helga Tryggvadottir, Andrea Markkula, Maria Simonsson, Björn Nodin, Karin Jirström, Carsten Rose, Christian Ingvar, Signe Borgquist and Helena Jernström

    BMC Clinical Pathology 2015 15:8

    Published on: 20 May 2015

  15. Research article

    Length of prostate biopsies is not necessarily compromised by pooling multiple cores in one paraffin block: an observational study

    Individually submitted prostatic needle biopsies are recommended by most guidelines because of their potential advantage in terms of core quality. However, unspecified bilateral biopsies are commonly submitted...

    Teemu T Tolonen, Jorma Isola, Antti Kaipia, Jarno Riikonen, Laura Koivusalo, Sanna Huovinen, Marita Laurila, Sinikka Porre, Mika Tirkkonen and Paula Kujala

    BMC Clinical Pathology 2015 15:4

    Published on: 8 March 2015

  16. Research article

    SOD2 immunoexpression predicts lymph node metastasis in penile cancer

    Superoxide dismutase-2 (SOD2) is considered one of the most important antioxidant enzymes that regulate cellular redox state in normal and tumorigenic cells. Overexpression of this enzyme in lung, gastric, col...

    Lara Termini, José H Fregnani, Enrique Boccardo, Walter H da Costa, Adhemar Longatto-Filho, Maria A Andreoli, Maria C Costa, Ademar Lopes, Isabela W da Cunha, Fernando A Soares, Luisa L Villa and Gustavo C Guimarães

    BMC Clinical Pathology 2015 15:3

    Published on: 3 March 2015

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